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Eucommia ulmoides extract attenuates angiotensin II-induced cardiac microvascular endothelial cell dysfunction by inactivating p53

Hu, Liye; Xu, Xiaolin; Xiao, Xunli.
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract Angiotensin II (AngII) causes endothelial dysfunction. Eucommia ulmoides extract (EUE) is documented to manipulate AngII, but its impact on cardiac microvascular endothelial cell (CMVEC) function remains unknown. This study determines the effects of EUE on AngII-treated CMVECs. CMVECs were trea...
Eucommiaceae/efectos adversos, d0008040, Extractos Vegetales/efectos adversos, Células Endoteliales/clasificación, Factor A de Crecimiento Endotelial Vascular/análisis
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Sunitinib induced resistance of endothelial cells by up-regulating P-glycoprotein and PI3K/Akt pathway

Zhang, Rong; Huang, Limin; Pan, Di; Zhang, Wen.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Drug resistance is a crucial obstacle to achieve satisfactory chemotherapeutic effects. Numerous studies have shown that the PI3K/Akt signaling pathway plays a significant role in various processes of cellular events and tumor progression, while few studies have focused on the PI3K/Akt signaling...
Células Endoteliales/clasificación, Miembro 1 de la Subfamilia B de Casetes de Unión a ATP/efectos adversos, Resistencia a Medicamentos, Sunitinib/agonistas, Concentración 50 Inhibidora, Células Endoteliales/patología, Preparaciones Farmacéuticas/administración & dosificación, Western Blotting/instrumentación
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Quantitative analysis of effects of salvianic acid a combined with hydroxy safflower yellow a on rat endothelial cells after hypoxic injury using the combination index method

Fang, Zheyu; Ying, Yuqi; Jin, Weifeng; Xu, Huaping.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Cerebrovascular disease is the second most serious disease in the world. It has the features of high morbidity, high mortality and recurrence rate. Numerous research on the compatibility of Chinese medicine with effective ingredients of cerebral ischemia has been made during the past decades. Th...
Estudios de Evaluación como Asunto, Células Endoteliales/clasificación, d0444660, Carthamus tinctorius/efectos adversos, d0019210, d0025450, d0085160, Preparaciones Farmacéuticas/administración & dosificación, d0275610, Trastornos Cerebrovasculares/patología
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Protein malnutrition effects of perivascular bone marrow microenvironment on the regulation of hematopoiesis

Hastreiter, Araceli Aparecida.
Protein malnutrition (PM) causes anemia and leukopenia by reduction of hematopoietic precursors and impaired production of mediators that induce hematopoiesis, as well as structural and ultrastructural changes in the bone marrow (BM) extracellular matrix. Hematopoiesis occurs in the bone marrow (BM) in d...
Deficiencia de Proteína/complicaciones, Hematopoyesis, Células Endoteliales/clasificación, Microambiente Tumoral
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