Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells
Biol. Res; 52 (), 2019
BACKGROUND: Tumor microenvironment (TME) plays a vital role in determining the outcomes of radiotherapy. As an important component of TME, vascular endothelial cells are involved in the perivascular resistance niche (PVRN), which is formed by inflammation or cytokine production induced by ionizing radiat...
Carcinoma de Pulmón de Células no Pequeñas/radioterapia, Quinasa de la Caseína II/antagonistas & inhibidores, Células Endoteliales/efectos de la radiación, Neoplasias Pulmonares/tratamiento farmacológico, Inhibidores de Proteínas Quinasas/farmacología, Antraquinonas/farmacología, Citocinas/biosíntesis, Endotelio Vascular/citología, Naftiridinas/farmacología, Western Blotting