Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction
Biol. Res; 56 (), 2023
BACKGROUND: AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. The zebrafish genome contains two ambra1 paralogous genes (a and b), both...
Diferenciación Sexual, Pez Cebra/genética, Pez Cebra/metabolismo, Proteínas Adaptadoras Transductoras de Señales/metabolismo, Células Germinativas/metabolismo, Mamíferos/genética, Mamíferos/metabolismo, ARN Mensajero/metabolismo, Reproducción, Proteínas de Pez Cebra/genética, Proteínas de Pez Cebra/metabolismo