LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation

Xu, Sha; Xiong, Jun; Wu, Minjuan; Yang, Yu; Jiang, Junfeng; Ni, Haitao; Zhao, Yunpeng; Wang, Yue.

Braz. j. med. biol. res; 54 (2), 2021

Severe blockage in myeloid differentiation is the hallmark of acute myeloid leukemia (AML). Trdmt1 plays an important role in hematopoiesis. However, little is known about the function of Trdmt1 in AML cell differentiation. In the present study, Trdmt1 was up-regulated and miR-181a was down-regulated sig...

ADN (Citosina-5-)-Metiltransferasas/genética, Diferenciación Celular, Células HL-60, Leucemia Mieloide Aguda/genética, MicroARNs/genética

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Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia

Ding, Tianling; Li, Jialing; Sun, Jianhong; Fan, Xiaoman; Shi, Chunli; Zhou, Dong; Deng, Ruoyu.

Braz. j. med. biol. res; 54 (2), 2021

This study aimed to explore the correlation of kinesin family member 2A (KIF2A) expression with disease risk, clinical characteristics, and prognosis of acute myeloid leukemia (AML), and investigate the effect of KIF2A knockdown on AML cell activities in vitro. Bone marrow samples were collected from 176...

Apoptosis, Biomarcadores de Tumor/genética, Proliferación Celular, Técnicas de Silenciamiento del Gen, Células HL-60, Cinesinas/genética, Leucemia Mieloide Aguda/diagnóstico, Leucemia Mieloide Aguda/genética, Factores de Riesgo, Tasa de Supervivencia

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Polyphenolic extracts of walnut (Juglans regia) green husk containing juglone inhibit the growth of HL-60 cells and induce apoptosis

Soto-Maldonado, Carmen; Vergara-Castro, Mauricio; Jara-Quezada, John; Caballero-Valdés, Eduardo; Müller-Pavez, Andrea; Zúñiga-Hansen, María Elvira; Altamirano, Claudia.

Electron. j. biotechnol; 39 (), 2019

BACKGROUND: Juglone is a naphthoquinone currently obtained by chemical synthesis with biological activities including antitumor activity. Additionally, juglone is present in the green husk of walnut, which suggests evaluating the effect of GH extracts on carcinogenic cell lines. RESULTS: Walnut green hus...

Juglans/química, Apoptosis, Antioxidantes/metabolismo, Células HL-60/metabolismo, Polifenoles/metabolismo, Cromatografía Líquida de Alta Presión, Técnicas de Cultivo de Célula, Supervivencia Celular, Potencial de la Membrana Mitocondrial

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Efeitos citotóxicos, genotóxicos e epigenéticos do Bisfenol A em células HL-60, MCF-7 e em ratos

Ribeiro, André Luiz Teroso.

Bisfenol A (BPA) é um insumo largamente utilizado na produção de plástico policarbonato e amplamente difundido no meio ambiente, levando o ser humano à exposição crônica desde o período intrauterino. A literatura aponta a possibilidade de BPA aumentar o risco de diversos tipos de câncer, mas s�...

Bisfenol A Glicidil Metacrilato, Epigénesis Genética, Células HL-60/citología, Células MCF-7/citología, Ratas/clasificación, Diabetes Mellitus, Bifenilos Policlorados/agonistas

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Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancer cells

Guo, Jian-Ru; Chen, Qian-Qian; Lam, Christopher Wai-Kei; Zhang, Wei.

Biol. Res; 48 (), 2015

BACKGROUND: We have investigated the potential anticancer effects of karanjin, a principal furanoflavonol constituent of the Chinese medicine Fordia cauliflora, using cytotoxic assay, cell cycle arrest, and induction of apoptosis in three human cancer cell lines (A549, HepG2 and HL-60 cells). RESULTS: MT...

Antineoplásicos Fitogénicos/farmacología, Apoptosis/efectos de los fármacos, Benzopiranos/farmacología, Puntos de Control del Ciclo Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Fabaceae/química, Extractos Vegetales/farmacología, Benzopiranos/aislamiento & purificación, Células A549, Células HL-60, Células Hep G2

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Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells

Pieme, Constant Anatole; Santosh, Guru Kumar; Tekwu, Emmanuel Mouafo; Askun, Tülin; Aydeniz, Hatice; Ngogang, Jeanne Yonkeu; Bhushan, Shashi; Saxena, Ajit Kumar.

Biol. Res; 47 (), 2014

BACKGROUND: Zanthoxylum heitzii is a spice used to prepare several dishes and to treat tumors, syphilis, malaria, cardiac palpitations, urogenital infections in the west region of Cameroon, but the antitumor mechanisms and chemical composition are not yet investigated. This study was aimed to determine t...

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