SUMMARY: This study evaluated the phytochemical screening, antioxidant capacity, and in vitro anticancer activities of four plants namely, Gypsophila capillaris, Anabasis lachnantha, Haloxylon salicornicum, and Horwoodia dicksoniae which belong to four different families: Caryophyllaceae, Amaranthaceae, ...
Plantas Medicinales/química,
Metabolómica,
Antioxidantes/química,
Antineoplásicos/química,
Cromatografía Líquida de Alta Presión,
Técnicas In Vitro,
Fenoles/análisis,
Antocianinas/análisis,
Saponinas/análisis,
Células Hep G2/efectos de los fármacos,
Células MCF-7/efectos de los fármacos,
Antioxidantes/farmacología,
Antineoplásicos/farmacología,
Arabia Saudita,
Fitoquímicos
Background: Hepatocellular carcinoma (HCC) is one of the most diagnosed cancers worldwide. Chemoprevention of HCC can be achieved using natural or synthetic compounds that reverse, suppress, detect, or prevent cancer progression. Objectives: In this study, both the antiproliferat...
Cisplatin, the first platinum compound approved for cancer treatment, is widely used in the treatment of various cancers including hepatocellular carcinoma (HCC). HCC incidence rates rise globally. Epithelial mesenchymal transition (EMT) is implicated in cancer invasion and metastasis, which are associat...
Cisplatino/administración & dosificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Microscopía Confocal,
Células Cultivadas,
Antineoplásicos/administración & dosificación,
Cadherinas/efectos de los fármacos,
Cadherinas/genética,
Vimentina/efectos de los fármacos,
Vimentina/genética,
Factores de Transcripción de la Familia Snail/efectos de los fármacos,
Factores de Transcripción de la Familia Snail/genética,
Técnica del Anticuerpo Fluorescente,
Cadherinas/metabolismo,
Vimentina/metabolismo,
Factores de Transcripción de la Familia Snail/metabolismo,
Células Hep G2,
Invasividad Neoplásica,
Transición Epitelial-Mesenquimal
Cota tinctoria is a medicinal plant which has been used for management of cancer in folk medicine of various regions. The aim of present study is to investigate cytotoxic activity of different concentrations of hydroalcoholic extract of C. tinctoria flowers on gastric (AGS) and liver (Hep-G2) cancer ce...
Asteraceae/química,
Extractos Vegetales/administración & dosificación,
Neoplasias Hepáticas/tratamiento farmacológico,
Extractos Vegetales/farmacología,
Línea Celular Tumoral/efectos de los fármacos,
Anthemis/química,
Células Hep G2/efectos de los fármacos,
Neoplasias Gástricas/tratamiento farmacológico,
Antineoplásicos Fitogénicos/administración & dosificación,
Antineoplásicos Fitogénicos/farmacología,
Extractos Vegetales/química,
Antineoplásicos Fitogénicos/química,
Técnicas de Cultivo de Célula,
Compuestos Fenólicos/análisis,
Flavonoides/análisis
Abstract Xuezhikang (XZK) is an extract of Chinese red yeast rice. It has multiple protective effects in cardiovascular systems. However, the underlying mechanism by which XZK affects free fatty acid (FFA)-induced lipogenesis in hepatocellular steatosis model is still unknown. Herein, we investigated thi...
Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer-related death. Sorafenib is the first approved drug for the treatment of advanced HCC. Depression is frequent in cancer patients. Moreover, sorafenib might exert depression as an adverse drug reaction and paroxetine, a selective serotoni...
Background/aim: Autophagic cell death and apoptosis of tumor cells has become one of the main objectives in cancer treatment, whereas tumor cell lines are mainly used in studies for providing important data for the evaluation of potential anti cancer substances. In this study, our objecti...
INTRODUCCIÓN: La enfermedad del hígado graso no alcohólico (EHGNA) es la forma más común de enfermedad hepática. A nivel celular se caracteriza por la acumulación de triglicéridos (TG) en forma de gotas lipídicas (GL) dando lugar a esteatosis e inflamación. Entre los factores relevantes para la...
Verbenaceae/química,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico,
Hepatocitos/efectos de los fármacos,
Triglicéridos/análisis,
Etanol/química,
Células Hep G2/efectos de los fármacos,
Inflamación,
Técnicas de Cultivo de Célula,
Supervivencia Celular,
Reacción en Cadena de la Polimerasa,
Técnicas In Vitro,
Ácido Oléico
Background: Cell culture (spheroid and 2D monolayer cultures) is an essential tool in drug discovery. Piperlongumine (PLN), a naturally occurring alkaloid present in the long pepper (Piper longum), has been implicated in the regulation of GSTP1 activity. In vitro treatment of cancer cells with PLN increa...
The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) have demonstrated innumerous biological effects and pharmacological potential against different ...
