LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Effects of cinnamon oil and its main constituents, cinnamic acid and cinnamaldehyde, on 1 - methyl - 4 - phenyl - 1,2,3,6 - tetrahydropyridine - induced neurodegeneration in PC - 12 cells

Bahramsoltani, Roodabeh; Shahpiri, Zahra; Farzaei, Mohammad Hosein; Hosseinzadeh, Leila; Rezazadeh, Davood; Pourfarzam, Morteza; Rahimi, Roja.

Bol. latinoam. Caribe plantas med. aromát; 22 (6), 2023

Cinnamon ( Cinnamomum verum J. Presl) is a well - known medicinal plant considered as an effective treatment for neurological disorders based on Persian medicine . The aim of the present study was assessing the effect of cinnamon oil, cinnamic acid, and cinnamaldehyde,...

Cinnamomum zeylanicum/química, Cromatografía Líquida de Alta Presión, Enfermedades Neurodegenerativas/tratamiento farmacológico, Enfermedad de Parkinson/tratamiento farmacológico, Medicina Tradicional, Aceites Volátiles/administración & dosificación, Aceites Volátiles/química, Cinamatos, Acroleína/análogos & derivados, 1-Metil-4-fenil-1,2,3,6-Tetrahidropiridina, Modelos Animales de Enfermedad, Especies Reactivas de Oxígeno, Células PC12

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MicroRNA-146a inhibition promotes total neurite outgrowth and suppresses cell apoptosis, inflammation, and STAT1/MYC pathway in PC12 and cortical neuron cellular Alzheimer's disease models

Ma, Yinghui; Ye, Jiye; Zhao, Li; Pan, Dongmei.

Braz. j. med. biol. res; 54 (5), 2021

This study aimed to explore the effect of microRNA (miR)-146a inhibition on regulating cell apoptosis, total neurite outgrowth, inflammation, and STAT1/MYC pathway in Alzheimer's disease (AD). PC12 and cortical neuron cellular AD models were constructed by Aβ1-42 insult. For the former model, nerve ...

Enfermedad de Alzheimer/genética, Apoptosis, Inflamación, MicroARNs/genética, Proyección Neuronal, Neuronas, Células PC12, Factor de Transcripción STAT1

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Aged garlic extract and S-allylcysteine prevent apoptotic cell death in a chemical hypoxia model

Orozco-Ibarra, Marisol; Muñoz-Sánchez, Jorge; Zavala-Medina, Martín E; Pineda, Benjamín; Magaña-Maldonado, Roxana; Vázquez-Contreras, Edgar; Maldonado, Perla D; Pedraza-Chaverri, José; Chánez-Cárdenas, María Elena.

Biol. Res; 49 (), 2016

BACKGROUND: Aged garlic extract (AGE) and its main constituent S-allylcysteine (SAC) are natural antioxidants with protective effects against cerebral ischemia or cancer, events that involve hypoxia stress. Cobalt chloride (CoCl2) has been used to mimic hypoxic conditions through the stabilization of the...

Antioxidantes/farmacología, Apoptosis/efectos de los fármacos, Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/efectos de los fármacos, Cisteína/análogos & derivados, Ajo/química, Extractos Vegetales/farmacología, Hipoxia de la Célula/efectos de los fármacos, Supervivencia Celular/efectos de los fármacos, Cisteína/farmacología, Especies Reactivas de Oxígeno/análisis, Análisis de Varianza, Células Cultivadas, Cobalto, Citometría de Flujo, Formazáns, Células PC12, Sales de Tetrazolio

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