LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Zarzio Ameliorates Non-alcoholic Fatty Liver Induced By a High Fat Diet in a Rat Experimental Model: A Histological and Immunohistochemical Study

Baokbah, Tourki A. S.

Int. j. morphol; 41 (6), 2023

SUMMARY: The therapeutic effect of a granulocyte-colony stimulating factor (G-CSF) biosimilar drug, zarzio, on non-alcoholic fatty liver disease (NAFLD) in a rat model was investigated in this study. Thirty-two rats were randomly divided into four groups. Groups I and II were fed a standard laboratory di...

Factor Estimulante de Colonias de Granulocitos/administración & dosificación, Biosimilares Farmacéuticos/administración & dosificación, Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico, Modelos Animales de Enfermedad, Inmunohistoquímica, Factor de Necrosis Tumoral alfa/efectos de los fármacos, Células Secretoras de Insulina/efectos de los fármacos, Factor 2 Relacionado con NF-E2, d0009750, Dieta Alta en Grasa/efectos adversos, Caspasa 3

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Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Marafie, Sulaiman K; Al-Shawaf, Eman M; Abubaker, Jehad; Arefanian, Hossein.

Biol. Res; 52 (), 2019

BACKGROUND: Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-stimulated insulin secretion (GSIS). However, increased levels of FFAs lead to lipotox...

Células Secretoras de Insulina/efectos de los fármacos, Metabolismo de los Lípidos/efectos de los fármacos, Ácido Palmítico/toxicidad, Proteínas Proto-Oncogénicas c-akt/metabolismo, Serina-Treonina Quinasas TOR/metabolismo, Receptores Acoplados a Proteínas G/metabolismo, Células Secretoras de Insulina/metabolismo, Apoptosis, Línea Celular, Transducción de Señal

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Effect of wheatgrass on DNA damage, oxidative stress index and histological findings in diabetic rats

Mis, Leyla; Comba, Bahat; Uslu, Sema; Yeltekin, Asli.

Int. j. morphol; 36 (4), 2018

This study was aimed to search the effect of wheatgrass on the Total Antioxidan (TAS)-Oxidan Status (TOS) and DNA damage in rat with diabetes. The rats used in the study were randomly divided into 4 groups that each of has 10 rats: Control group; 1 ml single dose phosphate-citrate buffer injected i.p (pH...

Triticum/química, Extractos Vegetales/administración & dosificación, Diabetes Mellitus Experimental/tratamiento farmacológico, Antioxidantes/análisis, Estrés Oxidativo/efectos de los fármacos, Páncreas/efectos de los fármacos, Ratas Wistar, Daño del ADN/efectos de los fármacos, Oxidantes/sangre, Células Secretoras de Insulina/efectos de los fármacos, Extractos Vegetales/farmacología, Glucemia/efectos de los fármacos

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