ABSTRACT CD28 null T helper (Th) cells are rare in healthy individuals, but they are increased in various inflammatory and immune-mediated diseases. In this study, we determined the size of the CD4+/CD28 null T lymphocyte compartment in the peripheral blood of 40 autoimmune hemolytic anemia (AIHA) patien...
El cáncer gástrico (CG) es la neoplasia del tubo digestivo más prevalente en el mundo, asociada a factores genéticos del hospedero y externos, como infección por Helicobacter pylori. La patogénesis incluye inflamación crónica mediada por citocinas del microambiente tumoral, detectables sistémica...
Células TH1,
Neoplasias Gástricas/complicaciones,
Plasma/química,
Tracto Gastrointestinal/patología,
Adenocarcinoma/complicaciones,
Citocinas/análisis,
Infecciones por Helicobacter/complicaciones,
Inmunoglobulina G/análisis,
Interleucina-1/análisis,
Interleucina-10/análisis,
Interleucina-6/análisis,
Microambiente Tumoral,
Células Th2,
Células Th17,
Neoplasias/complicaciones,
Biomarcadores de Tumor/análisis
Abstract A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the posterior modulation of interferon- γ (IF...
ABSTRACT Objective Intrathyroid injection of dexamethasone (IID) was used for decrease the relapse rate of hyperthyroidism in the treatment of Graves' disease (GD), but the mechanism is still unclear. We aimed to explore the effect of IID on T help (Th)1/Th2 cells and their chemokine in patients with G...
ABSTRACT Objective: We evaluated the kinetics of cytokines belonging to the T helper1 (Th1), Th2, and Th17 profiles in septic patients, and their correlations with organ dysfunction and hospital mortality. Methods: This was a prospective observational study in a cohort of septic patients admitted to th...
Brasil/epidemiología,
Citocinas/sangre,
Mortalidad Hospitalaria,
Unidades de Cuidados Intensivos,
Modelos Logísticos,
Puntuaciones en la Disfunción de Órganos,
Valor Predictivo de las Pruebas,
Estudios Prospectivos,
Valores de Referencia,
Sepsis/sangre,
Sepsis/mortalidad,
Estadísticas no Paramétricas,
Células TH1/química,
Células Th17/química,
Células Th2/química,
Factores de Tiempo
ABSTRACT Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in th...
Líquidos Corporales/química,
Líquidos Corporales/inmunología,
Cuello del Útero/inmunología,
Cuello del Útero/patología,
Cuello del Útero/virología,
Estudios Transversales,
Citocinas/análisis,
Ensayo de Inmunoadsorción Enzimática,
Infecciones por HTLV-I/inmunología,
Infecciones por HTLV-I/patología,
Infecciones por HTLV-I/virología,
Virus Linfotrópico T Tipo 1 Humano/aislamiento & purificación,
Interleucina-17/inmunología,
Leucocitos Mononucleares/virología,
Clase Social,
Estadísticas no Paramétricas,
Células TH1/inmunología,
Células Th2/inmunología,
Vagina/inmunología,
Vagina/patología,
Vagina/virología,
Carga Viral
Abstract INTRODUCTION: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce. METHODS: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of c...
The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins in peripheral CD4+ T cells were quantified with qR...
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Apoptosis,
Artesunato/farmacología,
Artesunato/uso terapéutico,
Linfocitos T CD4-Positivos/citología,
Linfocitos T CD4-Positivos/efectos de los fármacos,
Diferenciación Celular,
Regulación hacia Abajo,
Citometría de Flujo,
Ratones Endogámicos C57BL,
MicroARNs/metabolismo,
Neoplasias Ováricas/tratamiento farmacológico,
Neoplasias Ováricas/inmunología,
Células TH1/citología,
Células TH1/efectos de los fármacos
SUMMARY Atopic dermatitis is a common skin disease. Its increased incidence has changed the focus of research on atopic dermatitis toward epidemiology, prevention, and treatment. Evidence suggests that intestinal microbiota plays an important role in the pathogenesis of atopic dermatitis inducing immunos...
ABSTRACT The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy...
Terapia Antirretroviral Altamente Activa,
Linfocitos T CD4-Positivos/inmunología,
Linfocitos T CD8-positivos/inmunología,
Citocinas/inmunología,
Infecciones por VIH/sangre,
Infecciones por VIH/inmunología,
Infecciones por VIH/virología,
Sobrevivientes de VIH a Largo Plazo,
VIH-1,
Inmunidad Celular/inmunología,
Células TH1/inmunología,
Células Th2/inmunología,
Carga Viral
