LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Intrathyroid injection of dexamethasone inhibits Th2 cells in Graves disease

ABSTRACT Objective Intrathyroid injection of dexamethasone (IID) was used for decrease the relapse rate of hyperthyroidism in the treatment of Graves' disease (GD), but the mechanism is still unclear. We aimed to explore the effect of IID on T help (Th)1/Th2 cells and their chemokine in patients with G...

Tangeretin has anti-asthmatic effects via regulating PI3K and Notch signaling and modulating Th1/Th2/Th17 cytokine balance in neonatal asthmatic mice

Liu, LL; Li, FH; Zhang, Y; Zhang, XF; Yang, J.

Braz. j. med. biol. res; 50 (8), 2017

Asthma is a chronic allergic disease characterized by airway inflammation, airway hyper-responsiveness (AHR), and mucus hypersecretion. T-lymphocytes are involved in the pathogenesis of asthma, mediating airway inflammatory reactions by secreting cytokines. The phosphoinositide 3-kinase (PI3K) and Notch ...

Animales Recién Nacidos, Antiasmáticos/uso terapéutico, Asma/tratamiento farmacológico, Asma/inmunología, Citocinas/efectos de los fármacos, Citocinas/inmunología, Modelos Animales de Enfermedad, Flavonas/uso terapéutico, Ratones Endogámicos BALB C, Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos, Proteínas Proto-Oncogénicas c-akt/inmunología, Transducción de Señal/efectos de los fármacos, Células TH1/efectos de los fármacos, Células TH1/inmunología, Células Th17/efectos de los fármacos, Células Th17/inmunología, Células Th2/efectos de los fármacos, Células Th2/inmunología

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