The aminoglycoside antibiotic gentamicin is able to alter metabolic activity and morphology of MDCK-C11 cells: a cell model of intercalated cells
Braz. j. med. biol. res; 51 (10), 2018
It is well known that the aminoglycoside antibiotic gentamicin is capable of causing damage to kidney cells. Given the known involvement of Ca2+ in the nephrotoxic action of gentamicin, the purpose of this study was to establish a relationship between the concentration of intracellular Ca2+ ([Ca2+]i) and...
Antibacterianos/toxicidad, Calcio/metabolismo, Membrana Celular/metabolismo, Supervivencia Celular/efectos de los fármacos, Células Clonales, Gentamicinas/toxicidad, Células de Riñón Canino Madin Darby/efectos de los fármacos, Células de Riñón Canino Madin Darby/metabolismo, Células de Riñón Canino Madin Darby/ultraestructura, Microscopía Electrónica de Rastreo, Modelos Animales, Nefronas/citología, Nefronas/efectos de los fármacos, Pruebas de Toxicidad/métodos