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Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion: a case-control study

Guaragna-Filho, Guilherme; Calixto, Antônio Ramos; Astur, Anna Beatriz Lima do Valle; Paula, Georgette Beatriz de; Oliveira, Laurione Cândido de; Morcillo, André Moreno; Gonçalves, Ezequiel Moreira; Mello, Maricilda Palandi de; Maciel-Guerra, Andrea Trevas; Guerra-Junior, Gil.
Säo Paulo med. j; 140 (2), 2022
Abstract BACKGROUND: Because normal male sexual differentiation is more complex than normal female sexual differentiation, there are more cases of disorders of sex development (DSDs) with 46,XY karyotype that have unclear etiology. However, Leydig and Sertoli cell markers are rarely used in distinguishi...
Estudios de Casos y Controles, Trastornos del Desarrollo Sexual, Gónadas/metabolismo, Cariotipo, Células de Sertoli/metabolismo, Testosterona/metabolismo
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Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation

Urriola-Muñoz, Paulina; Lizama, Carlos; Lagos-Cabré, Raúl; Reyes, Juan G; Moreno, Ricardo D.
Biol. Res; 47 (), 2014
BACKGROUND: Extracellular metolloproteases have been implied in different process such as cell death, differentiation and migration. Membrane-bound metalloproteases of the ADAM family shed the extracellular domain of many cytokines and receptor controlling auto and para/juxtacrine cell signaling in diffe...
Proteínas ADAM/metabolismo, Espermatogénesis/fisiología, Espermatozoides/metabolismo, Proteínas ADAM/análisis, Apoptosis/fisiología, Diferenciación Celular/fisiología, ARN Mensajero/análisis, Túbulos Seminíferos/química, Células de Sertoli/citología, Células de Sertoli/metabolismo, Espermátides/citología, Espermátides/metabolismo, Testículo/anatomía & histología, Receptor fas/análisis, Proteína ADAM10, Proteína ADAM17, Inmunohistoquímica, Ratas Sprague-Dawley, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
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