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Asymmetric Opening of Mitochondrial Permeability Transition Pore in Mouse Brain Hemispheres: A Link to the Mitochondrial Calcium Uniporter Complex

Batool, Mehvish; Fayyaz, Hajra; Alam, Muhammad Rizwan.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract The prolonged entry of large amounts of calcium into the mitochondria through the mitochondrial calcium uniporter complex (MCUC) may cause the permeability transition pore (mPTP) to open, which contributes to the pathogenesis of several diseases. Tissue-specific differences in mPTP opening due t...
Poro de Transición de la Permeabilidad Mitocondrial/análisis, Cerebro/anomalías, Ratones, 1-Metil-4-fenil-1,2,3,6-Tetrahidropiridina/efectos adversos, Calcio/agonistas, Corteza Renal, Encéfalo, Mitocondrias
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Ligustrazine suppresses platelet aggregation through inhibiting the activities of calcium sensors

Gao, Shuibo; Lei, Zhen; Wu, Hong.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Ligustrazine is widely used for the treatment of cardiovascular diseases in traditional Chinese medication. It has been reported that Ligustrazine decreases the concentration of intracellular calcium ions (Ca2+); however, the underlying mechanism remains unknown. In the present study, the effect...
Western Blotting/métodos, Agregación Plaquetaria, Pueblo Asiatico/clasificación, Calcio/agonistas, Adenosina Difosfato/farmacología, Enfermedades Cardiovasculares/patología, Moléculas de Interacción Estromal, Proteínas Quinasas
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Exuberant Vasospastic Angina Simulating Severe Three-Vessel Disease

Marmelo, Bruno; Abreu, Luís; Gil, Júlio; Ferreira, Pedro; Cabral, José.
Arq. bras. cardiol; 108 (6), 2017
Angina Pectoris Variable/diagnóstico por imagen, Angina Pectoris Variable/tratamiento farmacológico, Angina Pectoris Variable/fisiopatología, Angiografía, Calcio/agonistas, Vasoespasmo Coronario/diagnóstico por imagen, Vasoespasmo Coronario/fisiopatología, Diagnóstico Diferencial, Isosorbida/uso terapéutico
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