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Expression and cellular localisation of Trypanosoma cruzi calpains

Ennes-Vidal, Vítor; Pitaluga, André Nóbrega; Britto, Constança Felícia De Paoli de Carvalho; Branquinha, Marta Helena; Santos, André Luis Souza dos; Menna-Barreto, Rubem Figueiredo Sadok; dAvila-Levy, Claudia Masini.
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Calpains are present in almost all organisms and comprise a family of calcium-dependent cysteine peptidases implicated in crucial cellular functions. Trypanosoma cruzi, the causative agent of Chagas disease, presents an expansion on this gene family with unexplored biological properties. OBJ...
Western Blotting, Calpaína/genética, Calpaína/metabolismo, Enfermedad de Chagas, Estadios del Ciclo de Vida, ARN Mensajero, Trypanosoma cruzi/genética
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Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis

Ennes-Vidal, Vítor; Vitório, Bianca da Silva; Menna-Barreto, Rubem Figueiredo Sadok; Pitaluga, André Nóbrega; Gonçalves-da-Silva, Silvia Amaral; Branquinha, Marta Helena; Santos, André Luis Souza; d'Avila-Levy, Claudia Masini.
Mem. Inst. Oswaldo Cruz; 114 (), 2019
BACKGROUND Calpains are proteins belonging to the multi-gene family of calcium-dependent cysteine peptidases that undergo tight on/off regulation, and uncontrolled proteolysis of calpains is associated with severe human pathologies. Calpain orthologues are expanded and diversified in the trypanosomatids...
Western Blotting, Calpaína/efectos de los fármacos, Calpaína/genética, Calpaína/metabolismo, Calpaína/ultraestructura, Inhibidores de Cisteína Proteinasa/farmacología, Dipéptidos/farmacología, Citometría de Flujo, Regulación de la Expresión Génica, Genoma de Protozoos/genética, Inmunohistoquímica, Leishmania braziliensis/química, Leishmania braziliensis/genética, Leishmania braziliensis/metabolismo, Leishmania braziliensis/ultraestructura, Macrófagos Peritoneales/metabolismo, Ratones Endogámicos BALB C, Microscopía Electrónica de Transmisión, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Factores de Virulencia
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