LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Lidocaine in oncological surgery: the role of blocking in voltage-gated sodium channels. A narrative review

Abstract Background: The current evidence suggests that oncological surgery, which is a therapy used in the treatment of solid tumors, increases the risk of metastasis. In this regard, a wide range of tumor cells express Voltage-Gated Sodium Channels (VGSC), whose biological roles are not related to the...

Physiological and biochemical characterization of egg extract of black widow spiders to uncover molecular basis of egg toxicity

Yan, Yizhong; Li, Jianjun; Zhang, Yiya; Peng, Xiaozhen; Guo, Tianyao; Wang, Jirong; Hu, Weijun; Duan, Zhigui; Wang, Xianchun.

Biol. Res; 47 (), 2014

BACKGROUND: Black widow spider (L. tredecimguttatus) has toxic components not only in the venomous glands, but also in other parts of the body and its eggs. It is biologically important to investigate the molecular basis of the egg toxicity. RESULTS: In the present work, an aqueous extract was prepared f...

Proteínas de Artrópodos/toxicidad, Araña Viuda Negra/química, Óvulo/química, Extractos de Tejidos/química, Exoesqueleto/química, Exoesqueleto/fisiología, Proteínas de Artrópodos/aislamiento & purificación, Canales de Calcio/efectos de los fármacos, Cucarachas/efectos de los fármacos, Ganglios Espinales/efectos de los fármacos, Óvulo/fisiología, Nervio Frénico/efectos de los fármacos, Canales de Potasio con Entrada de Voltaje/efectos de los fármacos, Extractos de Tejidos/toxicidad, Canales de Sodio Activados por Voltaje/efectos de los fármacos

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