LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Lidocaine in oncological surgery: the role of blocking in voltage-gated sodium channels. A narrative review

Soto, German; Calero, Fernanda; Naranjo, Marusa.

Rev. bras. anestesiol; 70 (5), 2020

Abstract Background: The current evidence suggests that oncological surgery, which is a therapy used in the treatment of solid tumors, increases the risk of metastasis. In this regard, a wide range of tumor cells express Voltage-Gated Sodium Channels (VGSC), whose biological roles are not related to the...

Movimiento Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Lidocaína/farmacología, Metástasis de la Neoplasia/prevención & control, Neoplasias/patología, Neoplasias/cirugía, Bloqueadores del Canal de Sodio Activado por Voltaje/farmacología, Canales de Sodio Activados por Voltaje/efectos de los fármacos, Canales de Sodio Activados por Voltaje/metabolismo

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Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?

Breast cancer is the most common cancer among women and its metastatic potential is responsible for numerous deaths. Thus, the need to find new targets for improving treatment, and even finding the cure, becomes increasingly greater. Ion channels are known to participate in several physiological function...