LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The secreted acid trehalase encoded by the CgATH1 gene is involved in Candida glabrata virulence

Lopes, Rafael G; Muñoz, Julián E; Barros, Ludmila M; Alves-Jr, Sergio L; Taborda, Carlos P; Stambuk, Boris U.

Mem. Inst. Oswaldo Cruz; 115 (), 2020

BACKGROUND Candida glabrata yeast is the second cause of candidiasis worldwide. Differs from other yeasts since assimilates only glucose and trehalose (a characteristic used in rapid identification tests for this pathogen) by secreting into the medium a highly active acid trehalase encoded by the CgATH1 ...

Candida glabrata/genética, Candida glabrata/metabolismo, Candida glabrata/patogenicidad, Candida glabrata/fisiología, Candidiasis, Eliminación de Gen, Genes Fúngicos, Hidrolasas, Trehalasa/genética, Trehalasa/metabolismo, Trehalasa/fisiología, Trehalosa/análisis, Virulencia/genética, Virulencia/fisiología

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Characterisation of an ABC transporter of a resistant Candida glabrata clinical isolate

BACKGROUND Candida glabrata ranks second in epidemiological surveillance studies, and is considered one of the main human yeast pathogens. Treatment of Candida infections represents a contemporary public health problem due to the limited availability of an antifungal arsenal, toxicity effects and increas...