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Synergistic interaction of fluconazole/sodium bicarbonate on the inhibition of Candida glabrata phospholipase gene

Hosseini, Seyed Mohammad Karim; Alizadeh, Fahimeh; Nouripour-Sisakht, Sadegh; Khodavandi, Alireza.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Candida glabrata infections are responsible for deaths of people globally. Fluconazole is known to be less effective against C. glabrata, which developed many strategies to evade being destroyed by fluconazole. To achieve enhanced efficacy of fluconazole against C. glabrata, the interaction of f...
Fluconazol/agonistas, Bicarbonato de Sodio/agonistas, Fosfolipasas/antagonistas & inhibidores, Candida glabrata/patogenicidad, Eficacia, Infecciones
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The secreted acid trehalase encoded by the CgATH1 gene is involved in Candida glabrata virulence

Lopes, Rafael G; Muñoz, Julián E; Barros, Ludmila M; Alves-Jr, Sergio L; Taborda, Carlos P; Stambuk, Boris U.
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Candida glabrata yeast is the second cause of candidiasis worldwide. Differs from other yeasts since assimilates only glucose and trehalose (a characteristic used in rapid identification tests for this pathogen) by secreting into the medium a highly active acid trehalase encoded by the CgATH1 ...
Candida glabrata/genética, Candida glabrata/metabolismo, Candida glabrata/patogenicidad, Candida glabrata/fisiología, Candidiasis, Eliminación de Gen, Genes Fúngicos, Hidrolasas, Trehalasa/genética, Trehalasa/metabolismo, Trehalasa/fisiología, Trehalosa/análisis, Virulencia/genética, Virulencia/fisiología
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