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Screening microbially produced pentyl diacetic acid lactone using an Escherichia coli biosensor workflow

Gao, Meng; Zhang, Yue; Xue, Lei; Li, Jie; Zhou, Zhe; Li, Xiaodan; Zhou, Zhengxiong; Wang, Ren.
Electron. j. biotechnol; 66 (), 2023
BACKGROUND Cannabinoid compounds have been approved as prescription drugs for treating various human ailments. However, the production using both microbial and plant-based sources is timeconsuming and expensive because their yield is extremely low. Tetraketide synthase (TKS), the key enzyme in the biosyn...
Escherichia coli/química, Escherichia coli/aislamiento & purificación, Lactonas/química, Lactonas/aislamiento & purificación, Cannabinoides/química, Técnicas Biosensibles/métodos
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Therapeutic applications based on cannabinoids action

Plancarte-Sánchez, Ricardo; Mansilla-Olivares, Armando; Reyes-Pacheco, Víctor Alfonso De los; Meneses-González, Fernando.
Gac. méd. Méx; 155 (3), 2019
The interest on cannabinoids became evident between the 1940 and 1950 decades. Although the active substance of the plant was not known, a series of compounds with cannabinomimetic activity were synthesized, which were investigated in animals and clinically. The most widely tested was Δ6α, 10&#...
Cannabidiol/química, Cannabidiol/aislamiento & purificación, Cannabinoides/química, Cannabinoides/aislamiento & purificación, Cannabinoides/uso terapéutico, Cannabinol/química, Cannabinol/aislamiento & purificación, Cannabis/química
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