LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line

In breast cancer treatment, chemotherapy resistance is a major problem where many receptive tumors rebound and develop resistance. When provided in combination, cancer drugs are most successful, thus reducing the risk of developing resistant cancer cells. However, the evaluation of combination therapies ...

Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line

Viscarra, Tamara; Buchegger, Kurt; Jofre, Ignacio; Riquelme, Ismael; Zanella, Louise; Abanto, Michel; Parker, Alyssa C; Piccolo, Stephen R; Roa, Juan Carlos; Ili, Carmen; Brebi, Priscilla.

Biol. Res; 52 (), 2019

BACKGROUND: Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in the understanding...

Antineoplásicos/farmacología, Carboplatino/farmacología, Resistencia a Antineoplásicos/genética, Regulación Neoplásica de la Expresión Génica/efectos de los fármacos, Neoplasias Ováricas/genética, Transcriptoma/efectos de los fármacos, Muerte Celular/efectos de los fármacos, Muerte Celular/genética, Neoplasias Ováricas/tratamiento farmacológico, Neoplasias Ováricas/patología, Transcriptoma/genética, Línea Celular Tumoral, Fenotipo, Análisis de Secuencia de ARN, Transducción de Señal

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