A quimioprevenção do câncer refere-se ao uso de compostos naturais ou sintéticos para prevenir o desenvolvimento das neoplasias antes do estabelecimento da malignidade. O ácido butirico (AB) atua como um potente quimiopreventivo na hepatocarcinogênese, reduzindo o número e o tamanho de lesões pr�...
Interferon-β-1a (INF-β-1a) has gained significant attention due to its emerging applications in the treatment of different human diseases. Therefore, many researchers have attempted to produce it in large quantities and also in a biologically active form using different expression systems. In the prese...
Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer-related death. Sorafenib is the first approved drug for the treatment of advanced HCC. Depression is frequent in cancer patients. Moreover, sorafenib might exert depression as an adverse drug reaction and paroxetine, a selective serotoni...
Previously, we evaluated the effect of trichostatin A (TSA) on the expression of DNA methyltransferase 1 (DNMT1) in Hepatocellular Carcinoma (HCC). Fragile histidine triad (FHIT) and WW domain-containing oxidoreductase (WWOX) are two of the most common down-regulated genes in many cancers located on chro...
SUMMARY Malignant liver tumors are the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) accounts for 75-85% of these. Most patients are diagnosed at incurable stages. Palliative care is the appropriate treatment course in these circumstances (chemoembolization and sorafenib)...
Antineoplásicos/uso terapéutico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/mortalidad,
Carcinoma Hepatocelular/patología,
Métodos Epidemiológicos,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/mortalidad,
Neoplasias Hepáticas/patología,
Persona de Mediana Edad,
Estadificación de Neoplasias,
Cuidados Paliativos,
Sorafenib/uso terapéutico,
Resultado del Tratamiento
Dar, K K;
Ali, S;
Ejaz, M;
Nasreen, S;
Ashraf, N;
Gillani, S F;
Shafi, N;
Safeer, S;
Khan, M A;
Andleeb, S;
Mughal, T A.
Abstract Background Hepatocellular carcinoma is the most frequent primary malignancy of liver and accounts for as many as one million deaths worldwide in a year. Objectives The aim of the present study was to evaluate the anti-cancerous efficiency of Bergenia ciliata rhizome against diethylnitrosoami...
BACKGROUND: Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) cells is still unclear. The aim of this study was to investigate the effect of ropiva...
Anestésicos Locales/farmacología,
Apoptosis/efectos de los fármacos,
Carcinoma Hepatocelular/patología,
Caspasa 3/metabolismo,
Neoplasias Hepáticas/patología,
Ropivacaína/farmacología,
Apoptosis/fisiología,
Carcinoma Hepatocelular/metabolismo,
Proliferación Celular/efectos de los fármacos,
Neoplasias Hepáticas/metabolismo,
Mitocondrias/efectos de los fármacos,
Transducción de Señal/efectos de los fármacos,
Línea Celular Tumoral,
Citometría de Flujo,
Microscopía Confocal,
Microscopía Fluorescente
BACKGROUND: Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic prolifer...
Antineoplásicos Fitogénicos/farmacología,
Carcinoma Hepatocelular/tratamiento farmacológico,
Proliferación Celular/efectos de los fármacos,
Estrés del Retículo Endoplásmico/efectos de los fármacos,
Ficusina/farmacología,
Neoplasias Hepáticas/tratamiento farmacológico,
Apoptosis/efectos de los fármacos,
Carcinoma Hepatocelular/patología,
Ficusina/química,
Ficusina/uso terapéutico,
Neoplasias Hepáticas/patología,
Proteínas Serina-Treonina Quinasas/farmacología,
Transducción de Señal/efectos de los fármacos,
Línea Celular Tumoral
The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3), a tumor suppressor, is critical for the carcinogenesis and progression of different cancers, including hepatocellular carcinoma (HCC). To date, the roles of lncRNA MEG3 in HCC are not well illustrated. Therefore, this study used western...
Apoptosis/genética,
Carcinoma Hepatocelular/genética,
Carcinoma Hepatocelular/metabolismo,
Carcinoma Hepatocelular/patología,
Línea Celular Tumoral,
Proliferación Celular/genética,
Regulación Neoplásica de la Expresión Génica,
Neoplasias Hepáticas/genética,
Neoplasias Hepáticas/metabolismo,
Neoplasias Hepáticas/patología,
MicroARNs/genética,
MicroARNs/metabolismo,
Estadificación de Neoplasias,
ARN Largo no Codificante/genética,
ARN Largo no Codificante/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factores de Transcripción SOXC/genética,
Factores de Transcripción SOXC/metabolismo,
Activación Transcripcional,
Transfección,
Regulación hacia Arriba
BACKGROUND: Long non-coding RNA H19 (H19) plays an important role by regulating protein expression in different tissues and organs of the body. However, whether H19 induces hypoxia/reoxygenation (h/R) injury via increase of autophagy in the hepatoma carcinoma cells is unknown. RESULTS: H19 was expressed ...
Carcinoma Hepatocelular/metabolismo,
Hipoxia/metabolismo,
Neoplasias Hepáticas/metabolismo,
ARN Largo no Codificante/metabolismo,
Daño por Reperfusión/metabolismo,
Apoptosis/fisiología,
Autofagia/efectos de los fármacos,
Isquemia Encefálica/metabolismo,
Carcinoma Hepatocelular/patología,
Neoplasias Hepáticas/patología,
Oxígeno/metabolismo,
Regulación hacia Arriba/fisiología
