Hepatitis C virus infection (HCV) is the foremost reason of progressive hepatic fibrosis and cirrhosis, with an elevated risk of hepatocellular carcinoma (HCC) development. Medicinal plants have been used for human health benefits for several years, but their therapeutic potential needs to be explored. T...
BACKGROUND: Super-paramagnetic iron oxide nanoparticles (SPION) contain a chemotherapeutic drug and are regarded as a promising technique for improving targeted delivery into cancer cells. RESULTS: In this study, the fabrication of 5-fluorouracil (5-FU) was investigated with loaded Dextran (DEXSPION) usi...
Fluorouracilo/administración & dosificación,
Neoplasias Hepáticas/tratamiento farmacológico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Nanopartículas/administración & dosificación,
Expresión Génica/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Sistemas de Liberación de Medicamentos,
Polímeros,
Nanopartículas de Magnetita,
Preparaciones de Acción Retardada,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Citometría de Flujo
Background/aim: Autophagic cell death and apoptosis of tumor cells has become one of the main objectives in cancer treatment, whereas tumor cell lines are mainly used in studies for providing important data for the evaluation of potential anti cancer substances. In this study, our objecti...
BACKGROUND: Recently, there is increasing awareness focused on the identification of naturally occurring anticancer agents derived from natural products. Manuka honey (MH) has been recognized for its biological properties as antimicrobial, antioxidant, and anticancer properties. However, its antiprolifer...
OBJECTIVES: To evaluate the efficacy and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma (HCC). METHODS: We analyzed data from a cohort of patients with advanced HCC treated using systemic treatment according to the local institutional protocol. Patients were divided into ...
Sevoflurane (SEVO) is widely applied as an anesthetic, which exerts antitumor capacity in various cancers, including hepatocellular carcinoma (HCC). Previous studies indicated that long non-coding RNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) was upregulated, while microRNA-29a-3p (miR-29a-...
Sorafenib (SOR) resistance is still a significant challenge for the effective treatment of hepatocellular carcinoma (HCC). The mechanism of sorafenib resistance remains unclear. Several microRNAs (miRNAs) have been identified as playing a role in impairing the sensitivity of tumor cells to treatment. We ...
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/genética,
Línea Celular Tumoral,
Proliferación Celular,
Resistencia a Antineoplásicos,
Regulación Neoplásica de la Expresión Génica,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/genética,
MicroARNs/genética,
Fosfohidrolasa PTEN/genética,
Fosfatidilinositol 3-Quinasas/metabolismo,
Transducción de Señal,
Sorafenib/farmacología,
Serina-Treonina Quinasas TOR
SUMMARY Malignant liver tumors are the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) accounts for 75-85% of these. Most patients are diagnosed at incurable stages. Palliative care is the appropriate treatment course in these circumstances (chemoembolization and sorafenib)...
Antineoplásicos/uso terapéutico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/mortalidad,
Carcinoma Hepatocelular/patología,
Métodos Epidemiológicos,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/mortalidad,
Neoplasias Hepáticas/patología,
Persona de Mediana Edad,
Estadificación de Neoplasias,
Cuidados Paliativos,
Sorafenib/uso terapéutico,
Resultado del Tratamiento
Hepatocellular carcinoma (HCC) is one of the most common primary malignant tumors of the liver worldwide. Liver resection and transplantation are currently the only effective treatments; however, recurrence and metastasis rates are still high. Previous studies have shown that the epithelial-mesenchymal t...
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/genética,
Proliferación Celular/efectos de los fármacos,
Proliferación Celular/genética,
Modelos Animales de Enfermedad,
Ensayos de Selección de Medicamentos Antitumorales,
Transición Epitelial-Mesenquimal/efectos de los fármacos,
Isoflavonas/farmacología,
Isoflavonas/uso terapéutico,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/genética,
MicroARNs/genética,
Invasividad Neoplásica,
Fosfohidrolasa PTEN/genética,
Pirroles
