Background: Oral squamous cell carcinoma (OSCC) is the most frequently occurring malignant tumor of the head and neck region. Chk2 (Checkpoint kinase 2) is considered a tumor suppressor gene that acts on the cellular response to DNA damage. However, the role of Chk2 in OSCC prognosis is not yet fully und...
Nine tumor and various potential biomarkers were measured and combined the information to diagnose disease, all patients accepted fiber bronchoscopy brush liquid based cytologyand histopathology examination in order to reliably detect lung cancer. The samples from 314 Chinese lung cancer patients were ob...
Neoplasias Pulmonares/metabolismo,
Neoplasias Pulmonares/patología,
Carcinoma/metabolismo,
Carcinoma/patología,
Biomarcadores de Tumor/metabolismo,
Carcinoma de Células Escamosas/metabolismo,
Carcinoma de Células Escamosas/patología,
Adenocarcinoma/metabolismo,
Adenocarcinoma/patología,
Carcinoma de Células Pequeñas/metabolismo,
Carcinoma de Células Pequeñas/patología,
Inmunohistoquímica,
Sensibilidad y Especificidad,
Queratinas Tipo II/metabolismo,
Factores de Transcripción/metabolismo,
Proteínas Supresoras de Tumor/metabolismo,
Fragmentos de Péptidos/metabolismo,
Queratina-7/metabolismo,
Factor Nuclear Tiroideo 1/metabolismo,
Ácido Aspártico Endopeptidasas/metabolismo,
Antígeno CD56/metabolismo
El carcinoma escamoso vulvar puede desarrollarse de manera asociada o independiente a la infección por HPV. La relación entre la patogénesis, la clasificación, el perfil inmunohistoquímico, y el pronóstico ha sido estudiada con algunas discrepancias. El objetivo del trabajo fue observar la concorda...
Biomarcadores de Tumor,
Carcinogénesis,
Carcinoma de Células Escamosas/diagnóstico,
Carcinoma de Células Escamosas/metabolismo,
Inmunohistoquímica,
Papillomaviridae,
Infecciones por Papillomavirus,
Proteína p53 Supresora de Tumor/metabolismo,
Neoplasias de la Vulva/diagnóstico,
Neoplasias de la Vulva/metabolismo,
Verrugas
BACKGROUND: Cervical cancer (CC) ranks third in the morbidity and mortality of female cancer around the world. Derlin1 has been found to be overexpressed in several human cancers. However, it is still unclear about its roles in CC. The research aims to explore the relationship between Derlin1 and CC. MET...
Carcinoma de Células Escamosas/metabolismo,
Proteínas de la Membrana/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Transducción de Señal/fisiología,
Serina-Treonina Quinasas TOR/metabolismo,
Neoplasias del Cuello Uterino/metabolismo,
Carcinoma de Células Escamosas/patología,
Proteínas Proto-Oncogénicas c-akt/fisiología,
Neoplasias del Cuello Uterino/patología,
Apoptosis,
Línea Celular Tumoral,
Proliferación Celular,
Inmunohistoquímica,
Análisis por Matrices de Proteínas
The aim of this study was to explore the correlation of ezrin and galectin-3 expressions with prognosis in cervical cancer. The immunohistochemical method was applied to detect ezrin and galectin-3 expressions in normal cervix tissues (n=30), cervicitis tissues (n=28), cervical intraepithelial neoplasia ...
Adenocarcinoma/metabolismo,
Carcinoma Adenoescamoso/metabolismo,
Carcinoma de Células Escamosas/metabolismo,
31574/metabolismo,
Proteínas del Citoesqueleto/metabolismo,
Galectina 3/metabolismo,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Ganglios Linfáticos/metabolismo,
Metástasis Linfática,
Pronóstico,
Modelos de Riesgos Proporcionales,
Valores de Referencia,
Factores de Tiempo,
Neoplasias del Cuello Uterino/metabolismo
Abstract To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over 30 years with...
Abstract The aim of this study was to identify the expression of Ki-67 and MCM3 in oral squamous cell carcinoma (OSCC) as well as to address the correlation with patient survival and clinical features. Samples were collected from 51 patients with OSCC who presented for follow-up. Immunohistochemical expr...
Factores de Edad,
Biopsia,
Carcinoma de Células Escamosas/metabolismo,
Carcinoma de Células Escamosas/mortalidad,
Carcinoma de Células Escamosas/patología,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Antígeno Ki-67/análisis,
Antígeno Ki-67/metabolismo,
Metástasis Linfática,
Persona de Mediana Edad,
Componente 3 del Complejo de Mantenimiento de Minicromosoma/metabolismo,
Neoplasias de la Boca/metabolismo,
Neoplasias de la Boca/mortalidad,
Neoplasias de la Boca/patología,
Proteínas de Neoplasias/metabolismo,
Estadificación de Neoplasias,
Adhesión en Parafina,
Valores de Referencia,
Factores Sexuales,
Factores de Tiempo,
Carga Tumoral
ABSTRACT Objective: to evaluate the influence of Ki-67 and P16INK4a proteins immunohistochemical expressions on the clinical and morphological parameters of perioral squamous cell carcinoma induced with 9,10-dimethyl-1,2-benzanthracene (DMBA) in mice. Methods: we topically induced the lesions in the or...
Objective: to assess the prevalence of abnormalities found by computed tomography (CT) of the chest in patients with squamous cell carcinoma of the head and neck. Methods: we retrospectively analyzed chest CT exams of 209 patients with squamous cell carcinoma of the head and neck. The CT findings were st...
BACKGROUND: Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV). RESULTS: A higher bur...
