Comment on "Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer"
Rev. Assoc. Med. Bras. (1992, Impr.); 67 (10), 2021
Results: 12
Melittin suppresses growth and induces apoptosis of non-small-cell lung cancer cells via down-regulation of TGF-β-mediated ERK signal pathway
Braz. j. med. biol. res; 54 (2), 2021
The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells. This study also explored the potential anti-cancer mechanism of melittin in NSCLC cells. The results demonstrated that melittin suppre...
Apoptosis, Factor Apoptótico 1 Activador de Proteasas, Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico, Carcinoma de Pulmón de Células no Pequeñas/genética, Caspasa 3, Línea Celular Tumoral, Movimiento Celular, Regulación hacia Abajo, Regulación Neoplásica de la Expresión Génica, Neoplasias Pulmonares/tratamiento farmacológico, Neoplasias Pulmonares/genética, Sistema de Señalización de MAP Quinasas, Meliteno/farmacología, Invasividad Neoplásica, Factor de Crecimiento Transformador beta/metabolismo
Association of tumor mutation burden and epidermal growth factor receptor inhibitor history with survival in patients with metastatic stage III/IV non-small-cell lung cancer: A retrospective study
Clinics; 76 (), 2021
OBJECTIVES: Lung cancer is the leading cause of cancer-related deaths worldwide. However, factors associated with the survival of patients with advanced non-small-cell lung cancer (NSCLC) who received only hospice care are largely unclear. In this study, we aimed to determine the prognostic factors corre...
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico, Carcinoma de Pulmón de Células no Pequeñas/genética, Carcinoma de Pulmón de Células no Pequeñas/patología, Receptores ErbB/genética, Neoplasias Pulmonares/tratamiento farmacológico, Neoplasias Pulmonares/genética, Neoplasias Pulmonares/patología, Mutación, Estadificación de Neoplasias, Pronóstico, Inhibidores de Proteínas Quinasas/uso terapéutico, Estudios Retrospectivos
Biomarker testing for advanced lung cancer by next-generation sequencing; a valid method to achieve a comprehensive glimpse at mutational landscape
Appl. cancer res; 40 (), 2020
Background: Next-generation sequencing (NGS) based assay for finding an actionable driver in non-small-cell lung cancer is a less used modality in clinical practice. With a long list of actionable targets, limited tissue, arduous single-gene assays, the alternative of NGS for broad testing in one experim...
Real-world molecular testing and treatment patterns in brazilian patients with newly diagnosed locally advanced or metastatic NSCLC
Clinics; 75 (), 2020
OBJECTIVES: To evaluate the molecular testing and treatment patterns in a retrospective cohort of newly diagnosed treatment-naïve patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC). METHODS: This is an observational retrospective cohort study conducted across 10 cancer cent...
Brasil, Carcinoma de Pulmón de Células no Pequeñas/diagnóstico, Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico, Carcinoma de Pulmón de Células no Pequeñas/genética, Neoplasias Pulmonares/tratamiento farmacológico, Neoplasias Pulmonares/genética, Técnicas de Diagnóstico Molecular, Mutación, Inhibidores de Proteínas Quinasas, Estudios Retrospectivos
Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer
Rev Assoc Med Bras (1992); 66 (7), 2020
SUMMARY OBJECTIVE Long noncoding RNA neuroblastoma-associated transcript 1 (NBAT1) has been reported to be involved in cancer progression. However, the clinical significance of NBAT1 in non-small cell lung cancer (NSCLC) is still unclear. Our present research aimed to explore whether NBAT1 serves as a ...
Mutational profile by targeted next generation sequencing of non-small cell lung cancer in the Mexican population
Salud pública Méx; 61 (3), 2019
Abstract: Objective: Targeted next-generation sequencing (t-NGS) has revolutionized clinical diagnosis allowing multiplexed detection of genomic alterations. This study evaluated the profile of somatic mutations by t-NGS in Mexican patients with non-small cell lung cancer (NSCLC). Materials and method...
Epigenetics in non-small cell lung carcinomas
Salud pública Méx; 61 (3), 2019
Abstract: Objective: To perform a systematic review of the main epigenetic aberrations involved in non-small cell lung carcinomas' (NSCLC) diagnosis, progression, and therapeutics. Materials and methods: We performed a systematic review of the scientific literature on lung cancer epigenetics, focusin...
Carcinoma de Pulmón de Células no Pequeñas/diagnóstico, Carcinoma de Pulmón de Células no Pequeñas/genética, Carcinoma de Pulmón de Células no Pequeñas/terapia, Metilación de ADN/genética, Progresión de la Enfermedad, Epigénesis Genética, Histonas/genética, Neoplasias Pulmonares/diagnóstico, Neoplasias Pulmonares/genética, Neoplasias Pulmonares/terapia
Molecular profile of non-small cell lung cancer in northeastern Brazil
J. bras. pneumol; 45 (3), 2019
ABSTRACT Objective: To investigate the histological subtypes and mutational profiles of non-small cell lung cancer in Brazil, looking for correlations among histological subtypes, expression of anaplastic lymphoma kinase (ALK), EGFR mutation status, and programmed death-ligand 1 (PD-L1) expression. Met...
Adenocarcinoma/genética, Adenocarcinoma/patología, Quinasa de Linfoma Anaplásico/análisis, Antígeno B7-H1/análisis, Biopsia, Brasil, Carcinoma de Pulmón de Células no Pequeñas/genética, Carcinoma de Pulmón de Células no Pequeñas/patología, Genes erbB-1/genética, Inmunohistoquímica, Neoplasias Pulmonares/genética, Neoplasias Pulmonares/patología, Mutación, Valores de Referencia, Estudios Retrospectivos
TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
Biol. Res; 52 (), 2019
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it difficult to diagnose lung cancer at an early stage. To identify biomarkers for lung canc...
Antígenos de Diferenciación/genética, Carcinoma de Pulmón de Células no Pequeñas/genética, Proliferación Celular/genética, Regulación hacia Abajo/genética, Neoplasias Pulmonares/genética, Factor de Transcripción AP-2/genética, Biomarcadores de Tumor/análisis, Genes Supresores de Tumor/fisiología, ARN Mensajero/análisis, ARN Interferente Pequeño/análisis, Línea Celular Tumoral, Regulación Neoplásica de la Expresión Génica