Guarize, Juliana;
Rocco, Elena Guerini;
Marinis, Filippo de;
Sedda, Giulia;
Bertolaccini, Luca;
Donghi, Stefano Maria;
Casiraghi, Monica;
Tonno, Clementina Di;
Barberis, Massimo;
Spaggiari, Lorenzo.
ABSTRACT Objective: EBUS-TBNA cytological sampling is routinely performed for pathological diagnosis, mediastinal staging, and molecular testing in lung cancer patients. EBUS-TBNA samples are not formally accepted for testing programmed death-ligand 1 (PD-L1) expression. The objective of the study was t...
Harada, Guilherme;
Neffa, Maria Fernanda Batistuzzo Vicentini;
Bonadio, Renata Colombo;
Mendoza, Elizabeth Zambrano;
Caparica, Rafael;
Lauricella, Letícia Leone;
Takagaki, Teresa Yae;
Roitberg, Felipe Santa Rosa;
Terra, Ricardo Mingarini;
Castro Jr, Gilberto De.
ABSTRACT Objective: Adjuvant chemotherapy (AC) improves survival of patients with resected non-small cell lung cancer (NSCLC). However, the cisplatin-vinorelbine regimen has been associated with a significant risk of clinically relevant toxicity. We sought to evaluate the effectiveness, safety, and feas...
OBJECTIVES: Lung cancer is the leading cause of cancer-related deaths worldwide. However, factors associated with the survival of patients with advanced non-small-cell lung cancer (NSCLC) who received only hospice care are largely unclear. In this study, we aimed to determine the prognostic factors corre...
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Receptores ErbB/genética,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/genética,
Neoplasias Pulmonares/patología,
Mutación,
Estadificación de Neoplasias,
Pronóstico,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Estudios Retrospectivos
ABSTRACT Surgical resection is the primary treatment option for early-stage non-small cell lung cancer, lobectomy being considered the standard of care. In elderly patients, physiological characteristics can limit the suitability for surgery and the extent of resection. Sublobar resection (SLR) can be of...
ABSTRACT Objective: Lung cancer (LC) is one of the leading causes of death worldwide. Accurate mediastinal staging is mandatory in order to assess prognosis and to select patients for surgical treatment. EBUS-TBNA is a minimally invasive procedure that allows sampling of mediastinal lymph nodes (LNs). S...
Broncoscopía,
Carcinoma de Pulmón de Células no Pequeñas/diagnóstico por imagen,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Carcinoma de Pulmón de Células no Pequeñas/cirugía,
Biopsia por Aspiración con Aguja Fina Guiada por Ultrasonido Endoscópico/métodos,
Endoscopía,
Neoplasias Pulmonares/diagnóstico por imagen,
Neoplasias Pulmonares/patología,
Ganglios Linfáticos/diagnóstico por imagen,
Ganglios Linfáticos/cirugía,
Neoplasias del Mediastino/diagnóstico por imagen,
Mediastinoscopía/métodos,
Mediastino/cirugía,
Estadificación de Neoplasias,
Sensibilidad y Especificidad
SUMMARY AIM To examine the relationship between treatment response and hypoxia-inducible factor-1 alpha (HIF-1α) levels in patients with locally advanced non-small cell lung cancer (NSCLC) who received chemoradiotherapy (CRT). METHODS Eighty patients with NSCLC were included in the study and tre...
Adenocarcinoma/sangre,
Adenocarcinoma/patología,
Adenocarcinoma/terapia,
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico,
Biomarcadores de Tumor/sangre,
Carcinoma de Pulmón de Células no Pequeñas/sangre,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Carcinoma de Pulmón de Células no Pequeñas/terapia,
Quimioradioterapia,
Subunidad alfa del Factor 1 Inducible por Hipoxia/sangre,
Neoplasias Pulmonares/sangre,
Neoplasias Pulmonares/patología,
Neoplasias Pulmonares/terapia,
Persona de Mediana Edad
ABSTRACT Objective: To investigate the histological subtypes and mutational profiles of non-small cell lung cancer in Brazil, looking for correlations among histological subtypes, expression of anaplastic lymphoma kinase (ALK), EGFR mutation status, and programmed death-ligand 1 (PD-L1) expression. Met...
Adenocarcinoma/genética,
Adenocarcinoma/patología,
Quinasa de Linfoma Anaplásico/análisis,
Antígeno B7-H1/análisis,
Biopsia,
Brasil,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Genes erbB-1/genética,
Inmunohistoquímica,
Neoplasias Pulmonares/genética,
Neoplasias Pulmonares/patología,
Mutación,
Valores de Referencia,
Estudios Retrospectivos
Abstract Lafoensia pacari A. St. Hill has been used in traditional medicine as an anti-ulcerogenic and anti-inflammatory. Although there is an ethnopharmacological indication for cancer treatment, only a few studies have demonstrated its possible anticancer activity. Thus, the aims of this study were: (1...
BACKGROUND: Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer compounds from ethnomedicinally important species Polygonum barbatum. METHODS: The colu...
Antineoplásicos Fitogénicos/farmacología,
Apoptosis/efectos de los fármacos,
Benzofuranos/farmacología,
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Células Escamosas/tratamiento farmacológico,
Proliferación Celular/efectos de los fármacos,
Polygonum/química,
Antineoplásicos Fitogénicos/aislamiento & purificación,
Benzofuranos/química,
Benzofuranos/aislamiento & purificación,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Carcinoma de Células Escamosas/patología,
Polygonum/clasificación,
Línea Celular Tumoral
BACKGROUND: Currently, the prognosis of patients with non-small cell lung cancer (NSCLC) remains dismal; hence, it is critical to identify effective anti-NSCLC agents with limited side effects. This study aimed to evaluate the therapeutic potential of flavonoid compound vitexin in human NSCLC cells and t...
Antineoplásicos/farmacología,
Apigenina/farmacología,
Apoptosis/efectos de los fármacos,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Neoplasias Pulmonares/patología,
Fosfatidilinositol 3-Quinasas/efectos de los fármacos,
Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos,
Serina-Treonina Quinasas TOR/efectos de los fármacos,
Carcinoma de Pulmón de Células no Pequeñas/metabolismo,
Proliferación Celular/efectos de los fármacos,
Neoplasias Pulmonares/metabolismo,
Potencial de la Membrana Mitocondrial/efectos de los fármacos,
Mitocondrias/efectos de los fármacos,
Transducción de Señal/efectos de los fármacos,
Células A549,
Línea Celular Tumoral,
Ratones Desnudos
