LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Stingless bee propolis, metformin, and their combination alleviate diabetic cardiomyopathy

Abstract Background and aim: Stingless bee propolis, a resinous compound processed by mandibular secretion of stingless bees, is used for maintenance of hygiene and stability of beehives. Research on stingless bee propolis shows therapeutic properties attributed to polyphenols exhibiting antioxidative, a...

Astragalus polysaccharides improve cardiomyopathy in STZ-induced diabetic mice and heterozygous (SOD2+/-) knockout mice

Ju, J; Chen, W; Lai, Y; Wang, L; Wang, H; Chen, WJ; Zhao, X; Ye, H; LI, Y; Zhang, Y.

Braz. j. med. biol. res; 50 (8), 2017

Oxidative stress plays an important role in the development of diabetic cardiomyopathy. In the present study, we determined whether the effect of astragalus polysaccharides (APS) on diabetic cardiomyopathy was associated with its impact on oxidative stress. Streptozotocin (STZ)-induced diabetic mice and ...

Apoptosis/efectos de los fármacos, Planta del Astrágalo/química, Proliferación Celular/efectos de los fármacos, Diabetes Mellitus Experimental/tratamiento farmacológico, Diabetes Mellitus Experimental/patología, Cardiomiopatías Diabéticas/tratamiento farmacológico, Cardiomiopatías Diabéticas/patología, Ratones Endogámicos C57BL, Ratones Noqueados, Microscopía Electrónica de Transmisión, Miocitos Cardíacos/efectos de los fármacos, Miocitos Cardíacos/ultraestructura, Estrés Oxidativo/efectos de los fármacos, Extractos Vegetales/uso terapéutico, Polisacáridos/uso terapéutico, Estreptozocina, Superóxido Dismutasa/genética

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