SUMMARY: Cadmium (Cd) is a toxic element that accumulates in kidney and liver. L-carnitine(LC) is a natural compound that has been shown to exhibit antioxidant activity. Aim of this study was to investigate the effect of L-carnitine against cadmium-induced changes in liver and kidney tissues in prepubert...
SUMMARY: Cadmium (Cd) is the industrial and environmental toxic heavy metal which is found in air, water and soil. Cd, adversely affects many organs in humans such as kidney, intestine, liver, testis and lungs. L-carnitine (LC) is an important agent that plays essential role in energy metabolism. In our ...
SUMMARY: Ischemia-reperfusion (I/R) of the small intestine causes serious abdominal pathologies including tissue dysfunction and organ failure. L-carnitine (L-C), a powerful antioxidant, may help lessen the severity of these pathological effects since it plays a key role in energy metabolism. In this wor...
Resumo Fundamentos A L-carnitina (LC) tem muitos efeitos benéficos em animais diabéticos e humanos, mas seu efeito regulatório sobre a quemerina como uma citocina inflamatória e seu receptor no estado diabético são desconhecidos. Objetivos O presente estudo teve como objetivo investigar o efeit...
RESUMEN Objetivos: Evaluar el rol de la L-carnitina (LC) sobre el estrés oxidativo inducido por fructosa en ratas Holtzman. Materiales y métodos: Se realizó un estudio experimental durante 56 días, con cuatro grupos: control, control+LC, fructosa y fructosa+LC. Los grupos con fructosa recibieron e...
Background: The objective of the study was to determine the oxidative stress (OS) intensity depending
on the nutritional status (NS) among end-stage renal disease patients treated with continuous ambulatory peritoneal dialysis (CAPD) and to investigate the effectiveness of medical strategies for the
corr...
Castilhos, Raphael Machado;
Augustin, Marina Coutinho;
Santos, José Augusto dos;
Pedroso, José Luiz;
Barsottini, Orlando;
Saba, Roberta;
Ferraz, Henrique Ballalai;
Vargas, Fernando Regla;
Furtado, Gabriel Vasata;
Polese-Bonatto, Marcia;
Rodrigues, Luiza Paulsen;
Sena, Lucas Schenatto;
Vargas, Carmen Regla;
Saraiva-Pereira, Maria Luiza;
Jardim, Laura Bannach;
Neurogenética, Rede.
ABSTRACT Background: Huntington's disease (HD), caused by an expanded CAG repeat at HTT, has no treatment, and biomarkers are needed for future clinical trials. Objective: The objective of this study was to verify if free carnitine and branched chain amino acids levels behave as potential biomarkers in H...
ABSTRACT Purpose: The aim of the present study was to measure the free carnitine and acylcarnitine levels in pterygium tissue and normal conjunctival tissue at the metabolomics level using tandem mass spectrometry. Methods: In this prospective, clinical randomized study, pterygium tissues and normal co...
Carnitina/análogos & derivados,
Carnitina/análisis,
Carnitina/metabolismo,
Conjuntiva/anomalías,
Conjuntiva/metabolismo,
Conjuntiva/cirugía,
Metabolómica,
Estudios Prospectivos,
Pterigion/metabolismo,
Pterigion/cirugía,
Espectrometría de Masas en Tándem
Abstract Purpose: To investigate the protective effect of L-carnitine on myocardial injury in rats with heatstroke. Methods: orty-eight rats were randomly divided into control, heatstroke and 25, 50 and 100 mg/kg L-carnitine groups. The last three groups were treated with 25, 50 and 100 mg/kg L-carniti...
