LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model

Zhang, Chun; Liao, Qi; Ming, Jiang-Hua; Hu, Ge-Liang; Chen, Qing; Liu, Shi-Qing; Li, Ya-Ming.

Acta cir. bras; 32 (6), 2017

Abstract Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model. Methods: Thirty-six 6-week-old Male SD rats were randoml...

Cartílago Articular/efectos de los fármacos, Cartílago Articular/metabolismo, Quitosano/farmacología, Modelos Animales de Enfermedad, Regulación de la Expresión Génica, Oligosacáridos/farmacología, Osteoartritis/metabolismo, Osteoprotegerina/efectos de los fármacos, Osteoprotegerina/metabolismo, Ligando RANK/metabolismo, Ratas Sprague-Dawley

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Role of HIF-1α signaling pathway in osteoarthritis: A systematic review

Abstract Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvir...