LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Morphometric analysis and pattern of protein and gene expression of apoptosis in focal cerebral ischemia in rats and the neuroprotetive action of hypothermia and ketoprofen

Tirapelli, Daniela P. C; Cirino, Mucio Luiz de Assis; Carvalho, Camila A. Melo de; Novais, Paulo Cezar; Figueredo, Rafael Zimak; Porsani, Lucas Barbosa; Gula, Isabella Stracieri; Rodrigues, Andressa Romualdo; Silva, Jairo Pinheiro da; Pereira, Adriana Lis; Lizarte Neto, Fermino Sanches; Schimming, Bruno Cesar; Tazima, Maria de Fátima Galli Sorita; Fazan, Valéria de Paula Sassoli; Carlotti-Jr, Carlos Gilberto; Tirapelli, Luis Fernando; Colli, Benedicto Oscar.

Int. j. morphol; 38 (3), 2020

This study aimed to investigate the morphometric and the pattern of protein and gene expression related to the extrinsic apoptotic pathway in experimental focal cerebral ischemia and the hole of neuroprotection with hypothermia and ketoprofen. For this analysis, 120 rats were randomly divided into 3 grou...

Isquemia Encefálica/terapia, Isquemia Encefálica/genética, Apoptosis/genética, Hipotermia Inducida, Cetoprofeno/farmacología, Fármacos Neuroprotectores/farmacología, Isquemia Encefálica/patología, Caspasa 8/genética, Caspasa 3/genética, Modelos Animales de Enfermedad, Inmunohistoquímica, Isquemia Encefálica/metabolismo, Reacción en Cadena en Tiempo Real de la Polimerasa

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Gene Polymorphisms in FAS (Rs3740286 and Rs4064) Are Involved in Endometriosis Development in Brazilian Women, but not those in CASP8 (rs13416436 and rs2037815)

Pissetti, Cristina Wide; Tanaka, Sarah Cristina Sato Vaz; Hortolani, Andrezza Cristina Cancian; Marqui, Alessandra Bernadete Trovó de.

Rev. bras. ginecol. obstet; 40 (8), 2018

Abstract Objective The present study aims to investigate the association between caspase-8 (CASP8) (rs13416436 and rs2037815) and Fas cell surface death receptor (FAS) (rs3740286 and rs4064) polymorphisms with endometriosis in Brazilian women. Methods In the present case-control study, 45 women with ...

Brasil, Estudios de Casos y Controles, Caspasa 8/genética, Endometriosis/genética, Polimorfismo Genético, Receptor fas/genética

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MicroRNA-122 regulates caspase-8 and promotes the apoptosis of mouse cardiomyocytes

Zhang, ZW; Li, H; Chen, SS; Li, Y; Cui, ZY; Ma, J.

Braz. j. med. biol. res; 50 (2), 2017

Cardiomyocyte apoptosis plays key roles in the pathogenesis of heart diseases such as myocardial infarction. MicroRNAs are important regulators of gene expression, which are also involved in the regulation of cardiomyocyte apoptosis. However, cardiomyocyte apoptosis regulated by microRNA (miR)-122 is lar...

Animales Recién Nacidos, Apoptosis/genética, Caspasa 8/genética, Expresión Génica/genética, Expresión Génica/fisiología, Ratones Endogámicos BALB C, MicroARNs/genética, MicroARNs/fisiología, Miocitos Cardíacos/patología

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