Cui, Xinyuan;
Li, Yifu;
Yuan, Shuguang;
Huang, Yao;
Chen, Xiaojun;
Han, Yachun;
Liu, Zhiwen;
Li, Zheng;
Xiao, Yang;
Wang, Youliang;
Sun, Lin;
Liu, Hong;
Zhu, Xuejing.
BACKGROUND: Alpha-kinase 1 (ALPK1) is a master regulator in inflammation and has been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic nephropathy (DN) mice. Pyroptosis is involved in high glucose (HG)-induced tubular cells injury, characterized by activation of Gasdermi...
SUMMARY: Skeletal muscle injury is an acute inflammatory condition caused by an inflammatory response. To reduce inflammatory cell infiltration and relieve skeletal muscle injury, efficient treatment is urgently needed. Nitric oxide is a free radical molecule reported to have anti-inflammatory effects. I...
Óxido Nítrico/farmacología,
Antiinflamatorios/farmacología,
Enfermedades Musculares/inducido químicamente,
Venenos Elapídicos/toxicidad,
Mioblastos/efectos de los fármacos,
Supervivencia Celular,
Ratas Sprague-Dawley,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Ensayo de Inmunoadsorción Enzimática,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Inflamación,
NG-Nitroarginina Metil Éster,
Caspasas,
Técnicas In Vitro
BACKGROUND: Oral cancer is one of the common malignant tumors of the head and neck. However, current treatments have numerous side effects, and drugs from natural sources may have better therapeutic potential. This research investigated the induction of apoptosis by α-hederin (α-HN), a constituent of P...
Ácido Oleanólico/análogos & derivados,
Ácido Oleanólico/metabolismo,
Saponinas/metabolismo,
Neoplasias de la Boca/metabolismo,
Caspasas,
Citometría de Flujo,
Proliferación Celular/efectos de los fármacos,
Neoplasias de Cabeza y Cuello/metabolismo,
Serina-Treonina Quinasas TOR/metabolismo,
Fosfatidilinositol 3-Quinasas/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Transducción de Señal/efectos de los fármacos,
Pulsatilla,
Ácido Oleanólico/farmacología,
Saponinas/farmacología,
Apoptosis/efectos de los fármacos,
Supervivencia Celular,
Western Blotting
Two new coordination polymers [Zn (bdc)(bpybzimH2)](DMF)0.5 (1, H2bdc=1,4-dicarboxybenzene, bpybzimH2=6,6′-bis-(1H-benzoimidazol-2-yl)-2,2′-bipyridine, DMF=N,N-dimethylformamide) and [Co (bpybzimH2)(sbc)]H2O (2, H2sbc=4-mercaptobenzoic acid) have been successfully prepared under solvothermal ...
Apoptosis/efectos de los fármacos,
Caspasas/metabolismo,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Ligandos,
Polímeros/química,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Neoplasias de la Columna Vertebral/enzimología,
Neoplasias de la Columna Vertebral/patología,
Transfección
ABSTRACT BACKGROUND: The role of villous atrophy in apoptosis, a distinctive feature of celiac disease, is a matter of controversy. The aim of this study was to determine the apoptosis rate through immunohistochemical staining for M30 and M65 in celiac disease cases. DESIGN AND SETTING: Analytical cr...
Lu, Yuting;
Zhang, Ruili;
Wang, Zhenying;
Zhou, Shuhua;
Song, Yali;
Chen, Lamei;
Chen, Nan;
Liu, Wenmin;
Ji, Canan;
Wu, Wangli;
Zhang, Li.
We constructed lentiviral vectors containing the human wild-type GJB6 gene and the mutant variants A88V and G11R. The three proteins were stably expressed by the Tet-on system in the HaCaT cell line and used to study the functional effect of the variants. The CCK-8 assay and flow cytometric analyses were...
Apoptosis/genética,
Caspasas/metabolismo,
Línea Celular,
Proliferación Celular/efectos de los fármacos,
Proliferación Celular/genética,
Células Cultivadas,
Conexina 30/fisiología,
Doxiciclina/farmacología,
Displasia Ectodérmica/genética,
Citometría de Flujo,
Mutación/efectos de los fármacos
Abstract Background: Local anesthetics (LAs) are generally considered as safe, but cytotoxicity has been reported for several local anesthetics used in humans, which is not well investigated. In the present study, the cytotoxicity of lidocaine, ropivacaine and the combination of lidocaine and ropivacain...
BACKGROUND: Heavy metals can cause great harm to Siberian tigers in the natural environment. Cadmium (Cd2+) is an environmental contaminant that affects multiple cellular processes, including cell proliferation, differentiation, and survival. It has been shown to induce apoptosis in a variety of cell typ...
Apoptosis/efectos de los fármacos,
Cadmio/toxicidad,
Fibroblastos/efectos de los fármacos,
Homeostasis/efectos de los fármacos,
Espacio Intracelular/efectos de los fármacos,
Tigres,
Apoptosis/genética,
Caspasas/análisis,
Caspasas/efectos de los fármacos,
Ciclo Celular/efectos de los fármacos,
Ensayo Cometa/veterinaria,
Fibroblastos/fisiología,
Homeostasis/fisiología,
Potencial de la Membrana Mitocondrial/efectos de los fármacos,
Especies Reactivas de Oxígeno/análisis,
Células Cultivadas,
Daño del ADN,
Microscopía Electrónica de Transmisión,
Reacción en Cadena de la Polimerasa,
Transcripción Reversa,
Siberia
BACKGROUND: Doxycycline (DC) has been shown to possess non-antibiotic properties including Fas/Fas Ligand (FasL)-mediated apoptosis against several tumor types in the concentration range of 10-40 µg/mL. However, the effect of DC in apoptotic signaling at much low concentrations was not studied. METHODS:...
Apoptosis/efectos de los fármacos,
Caspasas/efectos de los fármacos,
Doxiciclina/administración & dosificación,
Proteína Ligando Fas/efectos de los fármacos,
Doxiciclina/farmacología,
Western Blotting,
Relación Dosis-Respuesta a Droga,
Activación Enzimática,
Citometría de Flujo,
Células HeLa,
Células 3T3 NIH
Apoptose, ou morte celular programada, é um processo essencial para a manutenção do desenvolvimento dos seresvivos, sendo importante para eliminar células supérfluas ou defeituosas. Durante a apoptose, a célula sofre alterações morfológicas características desse tipo de morte celular. Tais alte...
