LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Two new mixed-ligand coordination polymers based on multi-N chelating ligand inhibit YAP expression and induce caspase-mediated spinal tumor cell apoptosis

Sun, Yi Fu; Shao, Li Wei; Chen, Qi; Gao, Xu; Li, Fang; Wu, Chang Yan.

Braz. j. med. biol. res; 52 (5), 2019

Two new coordination polymers [Zn (bdc)(bpybzimH2)](DMF)0.5 (1, H2bdc=1,4-dicarboxybenzene, bpybzimH2=6,6′-bis-(1H-benzoimidazol-2-yl)-2,2′-bipyridine, DMF=N,N-dimethylformamide) and [Co (bpybzimH2)(sbc)]H2O (2, H2sbc=4-mercaptobenzoic acid) have been successfully prepared under solvothermal ...

Apoptosis/efectos de los fármacos, Caspasas/metabolismo, Línea Celular Tumoral, Proliferación Celular/efectos de los fármacos, Supervivencia Celular/efectos de los fármacos, Ligandos, Polímeros/química, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Neoplasias de la Columna Vertebral/enzimología, Neoplasias de la Columna Vertebral/patología, Transfección

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Expression of M30 and M65 in celiac disease. Analytical cross-sectional study

Aksoy, Evrim Kahramanoglu; Simsek, Gülçin Güler; Torgutalp, Murat; Sapmaz, Ferdane Pirinççi; Akpinar, Muhammet Yener; Uzman, Metin; Nazligül, Yasar.

Säo Paulo med. j; 136 (6), 2018

ABSTRACT BACKGROUND: The role of villous atrophy in apoptosis, a distinctive feature of celiac disease, is a matter of controversy. The aim of this study was to determine the apoptosis rate through immunohistochemical staining for M30 and M65 in celiac disease cases. DESIGN AND SETTING: Analytical cr...

Apoptosis, Biomarcadores/metabolismo, Biopsia, Caspasas/metabolismo, Enfermedad Celíaca/metabolismo, Enfermedad Celíaca/patología, Estudios Transversales, Queratina-18/metabolismo

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Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis

Lu, Yuting; Zhang, Ruili; Wang, Zhenying; Zhou, Shuhua; Song, Yali; Chen, Lamei; Chen, Nan; Liu, Wenmin; Ji, Canan; Wu, Wangli; Zhang, Li.

Braz. j. med. biol. res; 51 (9), 2018

We constructed lentiviral vectors containing the human wild-type GJB6 gene and the mutant variants A88V and G11R. The three proteins were stably expressed by the Tet-on system in the HaCaT cell line and used to study the functional effect of the variants. The CCK-8 assay and flow cytometric analyses were...

Apoptosis/genética, Caspasas/metabolismo, Línea Celular, Proliferación Celular/efectos de los fármacos, Proliferación Celular/genética, Células Cultivadas, Conexina 30/fisiología, Doxiciclina/farmacología, Displasia Ectodérmica/genética, Citometría de Flujo, Mutación/efectos de los fármacos

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Cytotoxic effects of local anesthesia through lidocaine/ropivacaine on human melanoma cell lines

Kang, Ding-Kun; Zhao, Li-Yan; Wang, Hong-Li.

Rev. bras. anestesiol; 66 (6), 2016

Abstract Background: Local anesthetics (LAs) are generally considered as safe, but cytotoxicity has been reported for several local anesthetics used in humans, which is not well investigated. In the present study, the cytotoxicity of lidocaine, ropivacaine and the combination of lidocaine and ropivacain...

Amidas/toxicidad, Anestésicos Locales/toxicidad, Apoptosis/efectos de los fármacos, Caspasas/metabolismo, Línea Celular Tumoral, Supervivencia Celular/efectos de los fármacos, Relación Dosis-Respuesta a Droga, Citometría de Flujo, Lidocaína/toxicidad, Ropivacaína

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