LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

New multienzymatic complex formed between human cathepsin D and snake venom phospholipase A2

Moraes, Jeane do Nascimento; Francisco, Aleff Ferreira; Dill, Leandro Moreira; Diniz, Rafaela Souza; Oliveira, Claudia Siqueira de; Silva, Tainara Maiane Rodrigues da; Caldeira, Cleópatra Alves da Silva; Corrêa, Edailson de Alcântara; Coutinho-Neto, Antônio; Zanchi, Fernando Berton; Fontes, Marcos Roberto de Mattos; Soares, Andreimar Martins; Calderon, Leonardo de Azevedo.

J. venom. anim. toxins incl. trop. dis; 28 (), 2022

Background Cathepsin D (CatD) is a lysosomal proteolytic enzyme expressed in almost all tissues and organs. This protease is a multifunctional enzyme responsible for essential biological processes such as cell cycle regulation, differentiation, migration, tissue remodeling, neuronal growth, ovulation, an...

Fosfolipasas A2/análisis, Catepsina D/análisis, Complejos Multienzimáticos/química, Venenos Elapídicos/química

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Immunohistochemical Analysis of P-gp, LC3-II, and Cathepsin-D Associated with Histological Changes in Fish Liver: from the Impacted Environment to Clean Water

Abstract Herein we evaluated the histopathological alterations and expression patterns of multixenobiotic resistence (MXR) and autophagic proteins in liver samples of fish chronically exposed to anthropogenic contaminants in a highly polluted river, and then again after they had been transferred to good ...