SUMMARY: The objective of this study was to investigate the therapeutic wound healing potential and molecular mechanisms of shikonin as small molecules in vitro. A mouse burn model was used to explore the potential therapeutic effect of shikonin; we traced proliferating cells in vivo to locate the active...
Cicatrización de Heridas/efectos de los fármacos,
Quemaduras/tratamiento farmacológico,
Piel,
Modelos Animales de Enfermedad,
Técnicas In Vitro,
Fibroblastos,
Fosfatidilinositol 3-Quinasas,
Proteínas Proto-Oncogénicas c-akt,
Naftoquinonas/administración & dosificación,
Ratones Endogámicos C57BL,
Naftoquinonas/farmacología,
Proliferación Celular/efectos de los fármacos
Objetivo:Identificar propriedades químicas e farmacológicas do gênero Copaifera no tratamento de lesões e feridas. Método: Revisão integrativa da literatura realizada nas bases de dados LILACS, MEDLINE, PubMed, Taylor & Francis e Scopus, em janeiro de 2022, por meio da estratégia de busca: ...
Purpose: The effects of hesperidin application on the wound caused by esophageal burns were investigated in this study. Methods: Wistar albino rats were divided into three groups: Control group: only 1 mL of 0.09% NaCl was administered i.p. for 28 days; Burn group: An alkaline esophageal burn model was c...
Santos, Thais Menezes dos;
Sousa, Danieli Silva Feijó de;
Di Piero, Karina Chamma;
Todeschini, Adriane Regina;
Dias, Wagner Barbosa;
Oliveira, Catarina Amorim;
Santos, Elisabete Pereira dos;
Monteiro, Mariana Sato de Souza Bustamante;
Gomes, Maria Kátia;
Moura, Cristiano dos Reis;
Teixeira, Pedro Antônio Castelo;
Ricci-Junior, Eduardo;
Freitas, Zaida Maria Faria de.
Abstract Hydrogels are used for wound treatment, as they may contain one or more active components and protect the wound bed. Papain is one of the active substances that have been used with this purpose, alongside urea. In this paper, carboxypolymethylene hydrogels containing papain (2% and 10% concentra...
Abstract Polyphenolics from Rhizophora mangle (R. mangle) have shown wound healing and anti- inflammatory effects that may be potentiated by being associated with ascorbic acid, an important substance for collagen and elastin synthesis that plays a role in tissue repair. In our study, we aimed to formula...
Background: Numerous types of cancer are of substantial medical and social concern, posing a major challenge to modern medicine. Chemotherapeutic drugs include the use of nucleosides, which are composed of nucleic acid and sugar. Objective: This study aims to assess the impact of systemic chemotherapeuti...
Este trabalho teve como objetivo realizar uma revisão integrativa sobre a Ozonioterapia como prática complementar no tratamento de lesões em seres humanos. Efetuou-se busca sistematizada nos portais: Biblioteca virtual em saúde (BVS), Biblioteca virtual em saúde de medicinas tradicionais complementa...
Zhao, Dan;
Xiao, Jinli;
Qiang, Lijuan;
Deng, Xingwang;
An, Jingjing;
Zhang, Qing;
Zhao, Fang;
Ma, Jiaxiang;
Fang, Chao;
Guan, Guangyu;
Wu, Yinsheng;
Xie, Yan.
Purpose:
To investigate the active ingredients of walnut ointment (WO) and its mechanism in repairing wounds.
Methods:
The ingredients of WO were detected by gas chromatography–mass spectrometry. The effect of linoleic acid (LA) was tested by in vitro Alamar Blue (AB) reagent. Image J software, histol...
Bulhões, Apolônia Agnes Vilar de Carvalho;
Estevão, Lígia Reis de Moura;
Florencio-Silva, Rinaldo;
Simoes, Ricardo Santos;
Leite, Ana Greice Borba;
Cunha, Dayana Maria Serafim da Silva;
Ramos, Clécio Souza;
Soares, Érica Bruna de Andrade;
D’Emery, Marcela Barbosa;
Câmara, Cláudio Augusto Gomes da;
Evêncio-Neto, Joaquim.
Purpose:
To evaluate the effects of rosemary leaf essential oil-based ointments on the healing of rat skin lesions.
Methods:
Sixty adult male rats, with dorsal excisional skin wounds made surgically under anesthesia, were divided into three groups (n = 20): Sham group (untreated wounds); control group (...
Abstract Despite decades of research, wound healing remains a significant public health problem. This study aimed to develop and evaluate a topical sodium alginate gel containing vancomycin (Van) loaded MMT NPs for wound healing applications. Van was loaded in MMT at different conditions (pHs of 6, 7 and...
Técnicas In Vitro/métodos,
Vancomicina/agonistas,
Infección de Heridas/patología,
Alginatos/análisis,
Bentonita/antagonistas & inhibidores,
Cicatrización de Heridas/efectos de los fármacos,
Antibacterianos/clasificación,
ddcs0285700,
Espectroscopía Infrarroja por Transformada de Fourier/métodos,
Heridas y Lesiones/tratamiento farmacológico,
d0121060,
Preparaciones Farmacéuticas/administración & dosificación
