LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3'-untranslated region

Piranda, D N; Abreu, R B V; Freitas-Alves, D R; de Carvalho, M A; Vianna-Jorge, R.

Braz. j. med. biol. res; 51 (2), 2018

The inducible inflammatory enzyme cycloxigenase-2 is up-regulated in cancer, and favors tumor progression. Cycloxigenase-2 is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, which presents sequence variations in the promoter region (PR) and in the 3′-untranslated region (3′...

Línea Celular Tumoral, Ciclooxigenasa 2/genética, Ciclooxigenasa 2/metabolismo, Regulación Neoplásica de la Expresión Génica/genética, Genotipo, Haplotipos, Luciferasas/metabolismo, Células MCF-7, Mutagénesis Sitio-Dirigida, Polimorfismo de Nucleótido Simple, Regulación hacia Arriba

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Polymorphism of the cox-2 gene and susceptibility to colon and rectal cancer

ABSTRACT Background: The colorectal neoplasm is the fourth most common malignancy among males and the third among females. In the Western world is estimated that 5% of the population will develop it, making this disease a major public health problem. Aim: To analyze the prevalence of the polymorphism...