Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats
Braz. j. med. biol. res; 51 (2), 2018
Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to eval...
Lesión Renal Aguda/inducido químicamente, Lesión Renal Aguda/fisiopatología, Lesión Renal Aguda/prevención & control, Bosentán, Creatinina/sangre, Ciclosporina/toxicidad, Antagonistas de los Receptores de Endotelina/farmacología, Antagonistas de los Receptores de Endotelina/uso terapéutico, Hemodinámica, Immunoblotting, Inmunohistoquímica, Inmunosupresores/toxicidad, Riñón/efectos de los fármacos, Pirimidinas/farmacología, Ratas Wistar, Reproducibilidad de los Resultados, Urea/sangre