SUMMARY: The response of the immune system to harmful stimuli leads to inflammation, and the adverse effects of the toxic hepatitis chemical, thioacetamide (TAA) on the human body are well documented. This article investigated the degree of protection provided by the combined pleotropic drug, metformin (...
Metformina/farmacología,
Resveratrol/farmacología,
Tioacetamida/toxicidad,
Cirrosis Hepática/inducido químicamente,
Serina-Treonina Quinasas TOR,
Inflamación,
Factor de Necrosis Tumoral alfa,
Citocinas/antagonistas & inhibidores,
Sirolimus,
Inmunohistoquímica,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Cirrosis Hepática/tratamiento farmacológico
Hepatitis C virus infection (HCV) is the foremost reason of progressive hepatic fibrosis and cirrhosis, with an elevated risk of hepatocellular carcinoma (HCC) development. Medicinal plants have been used for human health benefits for several years, but their therapeutic potential needs to be explored. T...
Lourenço, Mariana Sandoval;
Zitelli, Patricia Momoyo Y.;
Cunha-Silva, Marlone;
Oliveira, Arthur Ivan N.;
Lima, Roque Gabriel Rezende de;
Souza, Evandro de Oliveira;
Oliveira, Claudia P.;
Sevá-Pereira, Tiago;
Carrilho, Flair J.;
Pessoa, Mario G.;
Mazo, Daniel F..
OBJECTIVES: Despite higher rates of sustained virologic response (SVR), important concerns remain when patients with decompensated cirrhosis due to hepatitis C virus (HCV) are treated with direct-acting antiviral agents (DAA). Questions include efficacy, safety, and the magnitude of liver function improv...
ABSTRACT Purpose: To delve into the influence of paeoniflorin (PA) on abating primary biliary cholangitis (PBC)-induced liver fibrosis and its causative role. Methods: Our team allocated the mice to control group, PA group, PBC group and PBC+PA group. We recorded the weight change of mice in each group...
ABSTRACT Introduction: Effective and long-term combined antiretroviral therapy (cART) has decreased morbidity and mortality in HIV-infected individuals. Despite treatment advances, HIV-infected children continue to develop noninfectious conditions, including liver fibrosis. Methods: Cross-sectional stu...
Aspartato Aminotransferasas,
Biomarcadores,
Brasil,
Estudios Transversales,
VIH,
Infecciones por VIH/complicaciones,
Infecciones por VIH/tratamiento farmacológico,
Infecciones por VIH/patología,
Hígado/diagnóstico por imagen,
Cirrosis Hepática/tratamiento farmacológico,
Cirrosis Hepática/patología
This study aimed to perform a meta-analysis to determine the efficacy and safety of emricasan. Nine databases were searched for clinical trials investigating the efficacy of emricasan treatment in patients with liver cirrhosis or fibrosis. A manual search was conducted to identify the missing trials. The...
Cirrosis Hepática/complicaciones,
Cirrosis Hepática/tratamiento farmacológico,
Ascitis/complicaciones,
Ascitis/tratamiento farmacológico,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Diuréticos/administración & dosificación,
Furosemida/administración & dosificación,
Quimioterapia Combinada,
Albúminas/administración & dosificación,
Ascitis/etiología,
Medicina Basada en la Evidencia
Resumen Se comunica el caso clínico de un varón, con antecedentes de una cirrosis hepática alcohólica y gota, usuario crónico de antiinflamatorios, incluyendo corticoesteroides. Consultó por una melena secundaria a una úlcera bulbar. Durante su internación presentó fiebre, tratándose con ceftri...
Cirrosis Hepática/tratamiento farmacológico,
Cirrosis Hepática/etiología,
Cirrosis Hepática/parasitología,
Estrongiloidiasis/complicaciones,
Estrongiloidiasis/tratamiento farmacológico,
Estrongiloidiasis/fisiopatología,
Antiparasitarios/uso terapéutico,
Ascitis/parasitología,
Líquido Ascítico/parasitología,
Ivermectina/uso terapéutico,
Strongyloides stercoralis/aislamiento & purificación,
Resultado del Tratamiento
Introduction: Despite the emergence of new treatments for HCV genotype 3 (HCV G3),
there is still a lack of data about this particular subgroup in Brazil. Our objective was
to describe clinical and sociodemographic variables and treatment profile of HCV G3
Brazilian patients.
Methods: This was a descript...
Hepatitis C/virología,
Ribavirina/uso terapéutico,
Genotipo,
Estudios Retrospectivos,
Hepatitis C/epidemiología,
Hepatitis C/tratamiento farmacológico,
Sofosbuvir/uso terapéutico,
Hepacivirus/genética,
Interferones/uso terapéutico,
Antivirales/uso terapéutico,
Cirrosis Hepática/tratamiento farmacológico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Privación de Tratamiento
Relata-se o caso de paciente do sexo masculino, atendido em um
hospital universitário, após quadro duvidoso e arrastado de alteração cardíaca e hipertireoidiana, com a propedêutica sequencial
própria para crise tireotóxica. Destaca-se a necessidade de identificação precoce da apresentação c...
Tirotoxicosis/diagnóstico,
Hipertiroidismo/diagnóstico,
Diagnóstico Diferencial,
Hipertiroidismo/tratamiento farmacológico,
Electrocardiografía,
Ecocardiografía,
Fibrilación Atrial/diagnóstico por imagen,
Insuficiencia Cardíaca Diastólica/diagnóstico por imagen,
Ultrasonografía,
Transaminasas/sangre,
Cirrosis Hepática/diagnóstico por imagen,
Cirrosis Hepática/tratamiento farmacológico,
Paracentesis,
Albúminas/análisis,
Hospitalización,
Tirotoxicosis/tratamiento farmacológico
