Dentro da área da nanotecnologia, o sistema drug delivery vem sendo amplamente utilizado, cujo objetivo é proporcionar uma maior eficácia dos ativos farmacêuticos, podendo envolver desde uma distribuição mais seletiva dentro do organismo até a taxa que as moléculas serão liberadas e/ou a atenuaÃ...
Objective: The aim of our study is to describe the progression-free survival (PFS) in patients with clinical stage (CS) II and III NSGCT with an RM after primary or secondary CT with negative serum markers (NSM). A residual mass (RM) in non-seminomatous germ cell tumors (NSGCT) after chemotherapy (CT) is...
SUMMARY: The aim of this study is to reveal the gonadoprotective effects of myricetin (MYC), which has many biological properties, on cisplatin (CP)-induced testicular damage in rats. For this purpose, 40 male Wistar albino rats were divided into 4 groups as Control (group given no treatment), MYC (group...
Flavonoides/administración & dosificación,
Flavonoides/farmacologÃa,
TestÃculo/lesiones,
TestÃculo/efectos de los fármacos,
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Respuesta al Choque Térmico,
Inflamación,
Ratas Wistar,
Receptor Toll-Like 4,
FN-kappa B,
InmunohistoquÃmica,
Etiquetado Corte-Fin in Situ
SUMMARY: Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, testosterone inhibition and apoptosis. Accordingly, this study was co...
Camellia sinensis/quÃmica,
Extractos Vegetales/farmacologÃa,
Té/quÃmica,
Infliximab/farmacologÃa,
Cisplatino/toxicidad,
TestÃculo/efectos de los fármacos,
Recuento de Espermatozoides,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores,
Apoptosis,
Estrés Oxidativo,
Inflamación,
Ratas Sprague-Dawley,
Extractos Vegetales/quÃmica,
InmunohistoquÃmica,
MalondialdehÃdo/análisis,
Glutatión/análisis,
TestÃculo/patologÃa
SUMMARY: The present study investigated the possible protective effects of melatonin on Bleomycin, Cisplatin and etoposide (BEP) chemotherapy regimens using immunohistochemistry. Forty male Wistar rats were divided into four groups of ten as; group 1 as untreated control; group 2 as BEP group which recei...
Bleomicina/efectos adversos,
Cisplatino/efectos adversos,
Etopósido/efectos adversos,
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos,
Melatonina/administración & dosificación,
Antioxidantes/administración & dosificación,
Apoptosis/efectos de los fármacos,
InmunohistoquÃmica,
Ratas Wistar,
Sustancias Protectoras,
AntÃgeno Nuclear de Célula en Proliferación,
Enfermedades Pulmonares/prevención & control,
Enfermedades Pulmonares/inducido quÃmicamente
Abstract Our aim was to evaluate the effects of cisplatin and dexamethasone alone and combined on gastric contractility and histomorphometry of BALB/c and C57BL/6 mice. BALB/c and C57BL/6 male mice (8-week-old) were randomly separated into: Control; Cisplatin (7.5 mg/Kg); Dexamethasone (2.0 mg/Kg); and D...
BACKGROUND: The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages of life. Exposure to these threats mainly occurs during cancer treatment and as an occupational hazard in radiation centers. The present study investigated the regenerative ability of adipose-...
Azoospermia/inducido quÃmicamente,
Azoospermia/metabolismo,
Azoospermia/patologÃa,
Células Madre Mesenquimatosas,
Antioxidantes/farmacologÃa,
Cisplatino/efectos adversos,
Estrés Oxidativo,
Semen,
Espermatozoides/metabolismo,
Espermatozoides/patologÃa,
TestÃculo/metabolismo,
Testosterona/farmacologÃa
Cisplatin, the first platinum compound approved for cancer treatment, is widely used in the treatment of various cancers including hepatocellular carcinoma (HCC). HCC incidence rates rise globally. Epithelial mesenchymal transition (EMT) is implicated in cancer invasion and metastasis, which are associat...
Cisplatino/administración & dosificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
MicroscopÃa Confocal,
Células Cultivadas,
Antineoplásicos/administración & dosificación,
Cadherinas/efectos de los fármacos,
Cadherinas/genética,
Vimentina/efectos de los fármacos,
Vimentina/genética,
Factores de Transcripción de la Familia Snail/efectos de los fármacos,
Factores de Transcripción de la Familia Snail/genética,
Técnica del Anticuerpo Fluorescente,
Cadherinas/metabolismo,
Vimentina/metabolismo,
Factores de Transcripción de la Familia Snail/metabolismo,
Células Hep G2,
Invasividad Neoplásica,
Transición Epitelial-Mesenquimal
Purpose:
The present study explored the role of melatonin in cisplatin-induced cardiac injury along with the possible role of brain-derived neurotrophic factor (BDNF) in melatonin-mediated effects.
Methods:
Wistar rats were administered cisplatin (10 mg/kg), and cardiac injury was assessed by measuring ...
SUMMARY: Cisplatin is a chemotherapeutic agent inducing liver and kidney damage. In this study, we intended to investigate the impact of kefir beverage, an essential probiotic and functional food, on liver and kidney damage induced by cisplatin. Wistar albino rats were divided into four groups: Control, ...
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Riñón/efectos de los fármacos,
HÃgado/efectos de los fármacos,
Kéfir,
Ratas Wistar,
InmunohistoquÃmica,
Urea/análisis,
Creatinina/análisis,
Apoptosis/efectos de los fármacos,
Alanina Transaminasa/análisis,
Aspartato Aminotransferasas/análisis,
Caspasa 3
