SUMMARY: The aim of this study is to reveal the gonadoprotective effects of myricetin (MYC), which has many biological properties, on cisplatin (CP)-induced testicular damage in rats. For this purpose, 40 male Wistar albino rats were divided into 4 groups as Control (group given no treatment), MYC (group...
Flavonoides/administración & dosificación,
Flavonoides/farmacología,
Testículo/lesiones,
Testículo/efectos de los fármacos,
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Respuesta al Choque Térmico,
Inflamación,
Ratas Wistar,
Receptor Toll-Like 4,
FN-kappa B,
Inmunohistoquímica,
Etiquetado Corte-Fin in Situ
SUMMARY: Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, testosterone inhibition and apoptosis. Accordingly, this study was co...
Camellia sinensis/química,
Extractos Vegetales/farmacología,
Té/química,
Infliximab/farmacología,
Cisplatino/toxicidad,
Testículo/efectos de los fármacos,
Recuento de Espermatozoides,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores,
Apoptosis,
Estrés Oxidativo,
Inflamación,
Ratas Sprague-Dawley,
Extractos Vegetales/química,
Inmunohistoquímica,
Malondialdehído/análisis,
Glutatión/análisis,
Testículo/patología
Purpose:
The present study explored the role of melatonin in cisplatin-induced cardiac injury along with the possible role of brain-derived neurotrophic factor (BDNF) in melatonin-mediated effects.
Methods:
Wistar rats were administered cisplatin (10 mg/kg), and cardiac injury was assessed by measuring ...
SUMMARY: Cisplatin is a chemotherapeutic agent inducing liver and kidney damage. In this study, we intended to investigate the impact of kefir beverage, an essential probiotic and functional food, on liver and kidney damage induced by cisplatin. Wistar albino rats were divided into four groups: Control, ...
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Riñón/efectos de los fármacos,
Hígado/efectos de los fármacos,
Kéfir,
Ratas Wistar,
Inmunohistoquímica,
Urea/análisis,
Creatinina/análisis,
Apoptosis/efectos de los fármacos,
Alanina Transaminasa/análisis,
Aspartato Aminotransferasas/análisis,
Caspasa 3
SUMMARY: The aim of this study was to determine the relationship of autophagy-enhancing rapamycin (RAPA) and autophagy- inhibitor 3-methyladenine (3-MA) with Nitric oxide synthases (NOS) in Cisplatin (CIS)-induced neurotoxicity in rats. Rats were divided into 4 groups (n=10): Control was applied saline, ...
Síndromes de Neurotoxicidad,
Sirolimus/farmacología,
Adenina/análogos & derivados,
Adenina/farmacología,
Óxido Nítrico Sintasa/efectos de los fármacos,
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Ratas Wistar,
Inmunohistoquímica,
Superóxido Dismutasa,
Catalasa,
Malondialdehído,
Interleucina-6,
Ensayo de Inmunoadsorción Enzimática
SUMMARY: The aim of this study is to determine the potential therapeutic effects of CAPE in CP-induced nephrotoxicity in rats. Cisplatin (CP) is an antineoplastic chemotherapeutic used for treatment of many cancer types but its applications may induce nephrotoxicity. Caffeic acid phenethyl ester (CAPE) i...
Riñón/efectos de los fármacos,
Alcohol Feniletílico/análogos & derivados,
Alcohol Feniletílico/farmacología,
Ácidos Cafeicos/farmacología,
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Estrés Oxidativo/efectos de los fármacos,
Inflamación,
Ratas Wistar,
Inmunohistoquímica,
Ensayo de Inmunoadsorción Enzimática
Abstract Introduction: The use of electron microscopy in the study of the inner ear has allowed us to observe minute details of the hair cells, especially in ototoxicity studies; however, the preparation of this material is a difficult and delicate task. In an attempt to simplify the handling of these m...
Cisplatino/toxicidad,
Cóclea/efectos de los fármacos,
Cóclea/ultraestructura,
Ácido Edético/administración & dosificación,
Cobayas,
Células Ciliadas Auditivas/efectos de los fármacos,
Células Ciliadas Auditivas/ultraestructura,
Microscopía Electrónica de Rastreo,
Órgano Espiral/efectos de los fármacos,
Órgano Espiral/ultraestructura,
Tetróxido de Osmio/administración & dosificación,
Cloruro de Tolonio/administración & dosificación
Abstract Introduction Cisplatin damages the auditory system and is related to the generation of free radicals. Glutathione peroxidase is an endogenous free radicals remover. Objective To investigate the mechanisms involved in otoprotection by N-acetylcys- teine through the expression of glutathione p...
Estrés Oxidativo/efectos de los fármacos,
Cisplatino/toxicidad,
Glutatión Peroxidasa/metabolismo,
Acetilcisteína/uso terapéutico,
Cisplatino/uso terapéutico,
Ratas Wistar,
Acetilcisteína/metabolismo,
Pérdida Auditiva Sensorineural/prevención & control,
Cóclea/efectos de los fármacos,
Antineoplásicos/toxicidad,
Depuradores de Radicales Libres/uso terapéutico,
Depuradores de Radicales Libres/metabolismo,
Microscopía Electrónica de Rastreo,
Técnica del Anticuerpo Fluorescente,
Potenciales Evocados Auditivos del Tronco Encefálico,
Cóclea/anatomía & histología,
Acetilcisteína/farmacología,
Depuradores de Radicales Libres/farmacología,
Radicales Libres
Cisplatin is an antineoplastic agent with neuropathy as one of its major side effect. However, effective treatment is lacking. Increasing evidence suggests that cisplatin might damage nerve capillaries leading to impaired functions of blood-nerve barrier (BNB) and neuropathy. This study was aimed to exam...
SUMMARY: Toxic effects of anti-cancer and other drugs on the normal tissues could be reduced by the herbal plants and their fractions. This study investigated the protective effect of Tribulus terrestris (TT) on Cisplatin- induced cytotoxicity germ cell apoptosis in male mice. In this experimental study,...
