LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach

Biembengut, Ísis Venturi; de Souza, Tatiana de Arruda Campos Brasil.

Mem. Inst. Oswaldo Cruz; 115 (), 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The solution of the SARS-CoV-2 Mpro structure allowed the investigation of potential inhibitors. This work aims to provide first evidences of the applic...

Betacoronavirus, COVID-19/tratamiento farmacológico, Simulación por Computador, Proteasas 3C de Coronavirus, Infecciones por Coronavirus/tratamiento farmacológico, Cisteína Endopeptidasas, Inhibidores de Proteasas/química, SARS-CoV-2, Relación Estructura-Actividad, Proteínas no Estructurales Virales/antagonistas & inhibidores

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Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)

da Silva, Felipe Moura A; da Silva, Katia Pacheco A; de Oliveira, Luiz Paulo M; Costa, Emmanoel V; Koolen, Hector HF; Pinheiro, Maria Lúcia B; de Souza, Antonia Queiroz L; de Souza, Afonso Duarte L.

Mem. Inst. Oswaldo Cruz; 115 (), 2020

BACKGROUND Since the World Health Organization (WHO) declared Coronavirus disease 2019 (COVID-19) to be a pandemic infection, important severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (nsp) have been analysed as promising targets in virtual screening approaches. Amon...

Betacoronavirus/efectos de los fármacos, COVID-19, Proteasas 3C de Coronavirus, Infecciones por Coronavirus, Cisteína Endopeptidasas, Flavonoides/farmacología, Glicósidos/farmacología, Simulación del Acoplamiento Molecular, Pandemias, Neumonía Viral, ARN Polimerasa Dependiente del ARN/antagonistas & inhibidores, SARS-CoV-2, Proteínas no Estructurales Virales/antagonistas & inhibidores

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PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity

FUKUSHIMA, Henrique; ALVES, Vanessa Tubero Euzebio; CARVALHO, Verônica Franco de; AMBRÓSIO, Lucas Macedo Batitucci; EICHLER, Rosangela Aparecida dos Santos; CARVALHO, Maria Helena Catelli de; SARAIVA, Luciana; HOLZHAUSEN, Marinella.

Braz. oral res. (Online); 31 (), 2017

Abstract Recent studies investigating protease-activated receptor type 2 (PAR-2) suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous st...

Adhesinas Bacterianas/análisis, Biomarcadores/análisis, Estudios de Casos y Controles, Periodontitis Crónica/patología, Cisteína Endopeptidasas/análisis, Índice de Placa Dental, Expresión Génica, Líquido del Surco Gingival/química, Pérdida de la Inserción Periodontal, Índice Periodontal, Porphyromonas gingivalis, Receptor PAR-2/análisis, Valores de Referencia, Índice de Severidad de la Enfermedad, Estadísticas no Paramétricas

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