Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages
Mem. Inst. Oswaldo Cruz; 112 (11), 2017
Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M. tuberculosis knockout strain for cdd gene was obtained by allelic replacement. Evaluation of ...
Citidina Desaminasa/biosíntesis, Citidina Desaminasa/genética, Desoxicitidina/biosíntesis, Desoxicitidina/genética, Técnicas de Inactivación de Genes, Macrófagos/microbiología, Mycobacterium tuberculosis/enzimología, Mycobacterium tuberculosis/crecimiento & desarrollo, Mycobacterium tuberculosis/patogenicidad, Factores de Tiempo