LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Classic and current concepts in adrenal steroidogenesis: a reappraisal

Kater, Claudio E; Giorgi, Rafael B; Costa-Barbosa, Flavia A.

Arch. endocrinol. metab. (Online); 66 (1), 2022

ABSTRACT Adrenal steroid biosynthesis and its related pathology are constant evolving disciplines. In this paper, we review classic and current concepts of adrenal steroidogenesis, plus control mechanisms of steroid pathways, distribution of unique enzymes and cofactors, and major steroid families. We hi...

Hiperplasia Suprarrenal Congénita/metabolismo, Andrógenos, Citocromo P-450 CYP11B2, Hiperaldosteronismo, Esteroides

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Testosterona inhibe la actividad de la aldosterona sintasa silvestre y quimérica in vitro

Vecchiola, Andrea; Fuentes, Cristóbal A; Carvajal, Cristian A; Campino, Carmen; Allende, Fidel; Tapia-Castillo, Alejandra; Lagos, Carlos F; Fardella, Carlos E.

Rev. méd. Chile; 149 (11), 2021

BACKGROUND: Familial hyperaldosteronism type I is caused by the generation of a chimeric aldosterone synthase enzyme (ASCE) which is regulated by ACTH instead of angiotensin II. We have reported that in vitro, the wild-type (ASWT) and chimeric aldosterone synthase (ASCE) enzymes are inhibited by progeste...

Aldosterona, Citocromo P-450 CYP11B2, Células HEK293, Espectrometría de Masas en Tándem, Testosterona/farmacología

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Contribution of rs1799998 polymorphism in CYP11B2 gene in susceptibility to preeclampsia

Bezerra, Kaio Raffael Valotta; Tanaka, Sarah Cristina Sato Vaz; Silva, Vanessa Resende Souza; Paschoinni, Marina Carvalho; Grecco, Roseane Lopes da Silva; Soardi, Fernanda Caroline; Balarin, Marly Aparecida Spadotto.

Rev. Bras. Saúde Mater. Infant. (Online); 20 (2), 2020

Abstract Objectives: the present study aimed to evaluate the association between the rs1799998 polymorphism of the CYP11B2 gene and the susceptibility to preeclampsia (PE) in a Brazilian population. Methods: the study group comprised 61 women who were diagnosed with PE. The control group included 116 w...

Polimorfismo Genético, Preeclampsia/genética, Sistema Enzimático del Citocromo P-450, Citocromo P-450 CYP11B2, Modelos Logísticos, Perfil Genético, Predisposición Genética a la Enfermedad, Marcadores Genéticos, Brasil

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Congenital hyperreninemic hypoaldosteronism due to aldosterone synthase deficiency type I in a Portuguese patient - Case report and review of literature

Lages, Adriana de Sousa; Vale, Beatriz; Oliveira, Patrícia; Cardoso, Rita; Dinis, Isabel; Carrilho, Francisco; Mirante, Alice.

Arch. endocrinol. metab. (Online); 63 (1), 2019

SUMMARY Hyperreninemic hypoaldosteronism due to aldosterone synthase (AS) deficiency is a rare condition typically presenting as salt-wasting syndrome in the neonatal period. A one-month-old Portuguese boy born to non-consanguineous parents was examined for feeding difficulties and poor weight gain. A la...

Citocromo P-450 CYP11B2/deficiencia, Fludrocortisona/administración & dosificación, Hipoaldosteronismo/congénito, Hipoaldosteronismo/diagnóstico, Hipoaldosteronismo/tratamiento farmacológico, Cloruro de Sodio/administración & dosificación

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