LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Differential Effect of ITE on the Aryl Hydrocarbon Receptor Signaling in Breast Cancer Tissue: A Histopathological Study

Li, Zhengdong; Cheng, Xiaolin; Zhuang, Zhigang; Wang, Kai.

Int. j. morphol; 41 (5), 2023

SUMMARY: Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is highly expressed in various types of cancers including breast cancer. However, the role of AhR with its endogenous ligand 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) on the progression...

Indoles/administración & dosificación, Tiazoles/administración & dosificación, Receptores de Hidrocarburo de Aril/efectos de los fármacos, Neoplasias de la Mama/patología, Indoles/farmacología, Tiazoles/farmacología, Receptores de Estrógenos, Inmunohistoquímica, Proliferación Celular/efectos de los fármacos, Citometría de Flujo, Ensayos de Migración Celular, Western Blotting, Línea Celular Tumoral/efectos de los fármacos, Citocromo P-450 CYP1A1/genética, Citocromo P-450 CYP1B1/genética

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CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women

Abstract: Objective: To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) and GSTT1 (indel) are associated with breast cancer (BC) among Mexican women. Materials and methods: 952 incident cases with histologically confirmed BC were matched by age (± 5 years)...