LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Impacts of cytochrome P450 2D6 (CYP2D6) genetic polymorphism in tamoxifen therapy for breast cancer impactos do polimorfismo genético do citocromo P450 2D6 (CYP2D6) na terapia com tamoxifeno para câncer de mama

Abstract Tamoxifen (TMX) is the main drug used both in pre and postmenopausal women as adjuvant treatment for hormone receptor-positive breast cancer. An important barrier to the use of TMXis the development ofdrug resistance causedby molecular processes related to genetic and epigenetic mechanisms, such...

Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population

Céspedes-Garro, Carolina; Rodrigues-Soares, Fernanda; Jiménez-Arce, Gerardo; Naranjo, María-Eugenia G; Tarazona-Santos, Eduardo; Fariñas, Humberto; Barrantes, Ramiro; Llerena, Adrián.

Rev. biol. trop; 64 (3), 2016

Abstract:CYP2C9, CYP2C19 and CYP2D6 metabolize around 40 % of drugs and their genes vary across populations. The Costa Rican population has a trihybrid ancestry and its key geographic location turns it into a suitable scenario to evaluate interethnic differences across populations. This study aims to des...

Alelos, Indio Americano o Nativo de Alaska/genética, Pueblo Asiatico/genética, Población Negra/genética, Costa Rica/etnología, Citocromo P-450 CYP2C19/genética, Citocromo P-450 CYP2C9/genética, Citocromo P-450 CYP2D6/genética, Frecuencia de los Genes, Genotipo, Polimorfismo Genético, Reacción en Cadena en Tiempo Real de la Polimerasa, Valores de Referencia, Autoinforme

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