LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Relationship between PI3K/mTOR/RhoA pathway-regulated cytoskeletal rearrangements and phagocytic capacity of macrophages

Bao, H R; Chen, J L; Li, F; Zeng, X L; Liu, X J.

Braz. j. med. biol. res; 53 (7), 2020

The objective of this study was to investigate the relationship between PI3K/mTOR/RhoA signaling regulated cytoskeletal rearrangements and phagocytic capacity of macrophages. RAW264.7 macrophages were divided into four groups; blank control, negative control, PI3K-RNAi, and mTOR-RNAi. The cytoskeletal ch...

Western Blotting, Citoesqueleto/metabolismo, Silenciador del Gen, Vectores Genéticos, Macrófagos/metabolismo, Fagocitosis/fisiología, Fosfatidilinositol 3-Quinasas/metabolismo, Células RAW 264.7, Interferencia de ARN, Reacción en Cadena en Tiempo Real de la Polimerasa, Transducción de Señal, Serina-Treonina Quinasas TOR/metabolismo, Transfección, Proteína de Unión al GTP rhoA/metabolismo

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Dact1 involvement in the cytoskeletal arrangement of cardiomyocytes in atrial fibrillation by regulating cx43

Hou, Jian; Yue, Yuan; Hu, Bo; Xu, Guangtao; Su, Ruibing; Lv, Linhua; Huang, Jiaxing; Yao, Jianping; Guan, Yuanjun; Wang, Keke; Wu, Zhongkai.

Rev. bras. cir. cardiovasc; 34 (6), 2019

Abstract Objective: To determine the role of the dishevelled binding antagonist of beta catenin 1 (DACT1) in the cytoskeletal arrangement of cardiomyocytes in atrial fibrillation (AF). Methods: The DACT1 expression and its associations with the degree of fibrosis and β-catenin in valvular disease ...

Proteínas Adaptadoras Transductoras de Señales/genética, Proteínas Adaptadoras Transductoras de Señales/metabolismo, Fibrilación Atrial/genética, Fibrilación Atrial/metabolismo, Fibrilación Atrial/fisiopatología, Movimiento Celular, Conexina 43/genética, Conexina 43/metabolismo, Citoesqueleto/metabolismo, Inmunohistoquímica, Miocitos Cardíacos/citología, Proteínas Nucleares/genética, Proteínas Nucleares/metabolismo

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Interação parasita-célula hospedeira: modificação de proteínas de Tripanosoma cruzi durante adesão à matriz extracelular

Mattos, Eliciane Cevolani.

A doença de Chagas foi incialmente descrita em 1090 e após mais de 100 anos de investigações sobre essa doença, ainda pouco se sabe sobre os mecanismos ativados no parasita durante sua adesão e invasão à célula hospedeira. Glicoproteínas de massa molecular de 85kDa localizadas na membrana do pa...

Factor C1 de la Célula Huésped/análisis, Fosforilación/efectos de los fármacos, Citoesqueleto/metabolismo, Trypanosoma cruzi/parasitología, Interacciones Huésped-Parásitos, Matriz Extracelular/clasificación, Glicoproteínas/análisis, Electroforesis en Gel Bidimensional/métodos, Espectrometría de Masas/métodos

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Histochemical Localization of Carbohydrates in Morphological Stages of Developing Human Minor Salivary Glands: A Comparative Study with Cytoskeletal Markers

Rêgo, Moacyr J. B. M; Cavalacanti, Carmelita L. B; Beltrão, Eduardo I. C; Sobral, Ana Paula V.

Int. j. morphol; 29 (2), 2011

Carbohydrates play a critical role in many cellular processes like disease, growth and development. In this work lectins, proteins that recognizes carbohydrate free or conjugated, were used as histochemical probes for carbohydrates localization in developing human minor salivary gland. Immunohistochemist...

Glándulas Salivales/crecimiento & desarrollo, Metabolismo de los Hidratos de Carbono, Inmunohistoquímica, Lectinas/metabolismo, Citoesqueleto/metabolismo, Biomarcadores

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