O insucesso do tratamento endodôntico é decorrente principalmente da presença de microrganismos remanescentes no canal radicular decorrente da dificuldade de remoção de biofilmes e das limitações dos irrigantes convencionais. Por este motivo, há necessidade de novas alternativas para a desinfecç...
Background: Therapeutic advances against cancer have not been as successful as expected and have adverse effects that patients rarely tolerate. A study in Peru identified favorable anticancer effects of Annona muricata (AM), a medicinal plant known as soursop, in C-678 mouse gastric adenocarcinoma. Howev...
Abstract Dexchlorpheniramine is a first-generation classical antihistamine, clinically used to treat allergies. The main objective of our study was to evaluate the effects of the dexchlorpheniramine reference standard (DCPA Ref. St) and a pharmaceutical formula on DNA in human peripheral blood mononuclea...
ABSTRACT Introduction: Although the efficacy of hydroxyurea (HU) in inhibiting erythrocyte sickling has been well demonstrated, the action of this drug on human neutrophils and the mechanism by which it improves the manifestations of the disease have not been studied thoroughly. We aimed to investigate ...
No mercado encontramos uma grande variedade de materiais endodônticos
disponibilizados para uso clínico, mas diversos estudos mostram divergências de
opiniões com relação ao comportamento biológico dos diferentes materiais. Este
trabalho teve como objetivos investigar a viabilidade celular, a expr...
Hydroxyapatite, chitosan, and carbon nanotube composite biomaterial were developed to improve bone healing. Previous studies suggested that a combination of biomaterials and mesenchymal stem cells (MSCs) can potentially help promote bone regeneration. In the present study, we first developed hydroxyapati...
Picanço Castro, Virgínia;
Moço, Pablo Diego;
Mizukami, Amanda;
Vaz, Leticia Delfini;
Pereira, Marcelo de Souza Fernandes;
Silvestre, Renata Nacasaki;
Azevedo, Júlia Teixeira Cottas de;
Bomfim, Aline de Sousa;
Abreu Neto, Mario Soares de;
Malmegrim, Kelen Cristina Ribeiro;
Swiech, Kamilla;
Covas, Dimas Tadeu.
ABSTRACT Introduction: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen indepen...
Introdução: A Punica granatum L. (PG), utilizada como medicamento fitoterápico, apresenta propriedades terapêuticas, anti-inflamatórias e antioxidante. Embora diversos estudos já tenham sido realizados com este fitoterápico, seus possíveis efeitos citotóxicos nos tecidos humanos ainda não são ...
Granada (Fruta),
Medicamento Fitoterápico,
Antiinflamatorios,
Antioxidantes,
Fibroblastos,
Técnicas de Cultivo de Célula,
Mucosa Bucal,
Carcinoma de Células Escamosas,
Plantas Medicinales,
Citotoxicidad Inmunológica,
Neoplasias
Kuntjoro, Mefina;
Prasetyo, Eric Priyo;
Cahyani, Febriastuti;
Kamadjaja, Michael Josef Kridanto;
Hendrijantini, Nike;
Laksono, Harry;
Rahmania, Primanda Nur;
Ariestania, Vivin;
Nugraha, Alexander Patera;
Ihsan, Igo Syaiful;
Dinaryanti, Aristika;
Rantam, Fedik Abdul.
Abstract Objective: To show the cytotoxicity of Porphyromonas gingivalis lipopolysaccharide (LPS) on human umbilical cord mesenchymal stem cells (HUCMSCs) to better understand the characteristics for its application in regenerative procedures under periodontopathogen LPS influence. Material and Methods...
Beta-cardiotoxin (β-CTX), the three-finger toxin isolated from king cobra (Ophiophagus hannah) venom, possesses β-blocker activity as indicated by its negative chronotropy and its binding property to both β-1 and β-2 adrenergic receptors and has been proposed as a novel β-blocker candidate. Previous...
