Background: Moringa peregrina Forssk is a well-known plant in ethnomedicine due to its widespread uses in various diseases like cough, wound healing, rhinitis, fever, and detoxification. The plant seeds contain compounds that are cytotoxic to many cancer cells. During the therapeutic use of plants via th...
Background: Mammary gland tumors are the most prevalent neoplasm in intact female dogs, and they are good natural models to study comparative oncology. Most canine mammary malignancies, as in women, are commonly refractory to conventional therapies and demand continuous new therapeutic approaches. Crotal...
Annona muricata Linn. (Annonaceae) is a tropical plant with multiple beneficial health effects including anticancer properties. In breast cancer patients, overexpression of the HER2 oncoprotein corresponds to a poor prognosis, thus the main purpose of this study was to evaluate the cytotoxici...
Abstract The main aim of the study is to quantify the cytotoxic property of the Fucoidan extracted from the Turbinaria conoides using the MTT assay with the standard fucose. Fucoidan was extracted using the soaked water method and it was determined using the HPLC procedure the obtained Test sample Fucoid...
Técnicas In Vitro/instrumentación,
Células MCF-7,
Células A549,
Citotoxinas/efectos adversos,
Cromatografía Líquida de Alta Presión/métodos,
Concentración 50 Inhibidora,
Fibroblastos/clasificación,
Fucosa/análogos & derivados,
Línea Celular,
Neoplasias Pulmonares/patología,
Neoplasias de la Mama/patología
Picoli, T;
Peter, C. M;
Lopes, M. G;
Barcelos, L. S;
Varela Júnior, A. S;
Corcini, C. D;
Hübner, S. O;
Vargas, G. A;
Lima, M;
Fischer, G.
In this study, the toxic effects of melittin on Madin-Darby Bovine Kidney cells (MDBK) were analyzed with respect to mitochondrial functionality by reduction of MTT and flow cytometry, apoptosis potential, necrosis, oxygen reactive species (ROS) production, lipid peroxidation, and DNA fragmentation using...
This study evaluated the genotoxicity of lyophilized glycolic extract of Theobroma cacao Linné seeds (TCL), using the micronucleus assay in bone marrow of mice. The interaction between TCL and doxorubicin (DXR) was also analyzed. Experimental groups were evaluated 24-48 h after treatment with N-Nitroso-...
Santos, Débora Silva;
Moura, Ludmilla David de;
Radicchi, Marina Arantes;
Azevedo, Ricardo Bentes;
Costa, Maria Célia Pires;
Souza, Paulo Eduardo Narcizo de;
Camara, Adriana Leandro;
Silva, Jaqueline Rodrigues da;
Muehlmann, Luís Alexandre;
Longo, João Paulo Figueiró.
HIGHLIGHTS Production of lipid nanoemulsions (<100 nm) of industrial interest with low energy demand. The antioxidant properties of babassu oil have been improved and the nanoemulsions are not cytotoxic. Babassu oil is a food and medicinal product. The nanoemulsion is strategic for the developed...
HIGHLIGHTS The phenolic composition, antioxidant activity and cytotoxic potential of the extracts of C. solstitialis and U. picroides were investigated. Caffeic acid was found as the most abundant phenolic compound in the extracts. Both species showed promising antioxidant activity towards different...
Antioxidantes/farmacología,
Asteraceae/química,
Centaurea/química,
Compuestos Fenólicos/análisis,
Ácidos Cafeicos/farmacología,
Fenoles/farmacología,
Extractos Vegetales/farmacología,
Cromatografía Líquida de Alta Presión,
Turquía,
Plantas Medicinales,
Citotoxinas/farmacología,
Células HEK293
Picoli, T;
Peter, C. M;
Lopes, M. G;
Barcelos, L. S;
Varela Júnior, A. S;
Corcini, C. D;
Lima, M;
Hübner, S. O;
Vargas, G. D. A;
Fischer, G.
Among the immune system cells, macrophages have an important role. Apamin, a bee venom constituent, is important in the defense of these insects. Thus, we aimed to evaluate the metabolism of J774 1.6 macrophage cell line when exposed to isolated and purified apamin, using cytotoxicity tests by MTT reduct...
El presente estudio tiene como objetivo explorar las posibles aplicaciones de los extractos de corteza y hoja de Blepharocalyx
cruckshanksii como agente citotóxico contra líneas celulares de cáncer in vitro ((MCF-7, PC-3 y HT-29) mediante el uso de ensayo de
sulforhodamine B (SRB). El ensayo de citoto...
