LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Pituitary Adenylate Cyclase Activating Peptide (1-38) and its analog (Acetyl-[Ala15, Ala20] PACAP 38-polyamide) reverse methacholine airway hyperresponsiveness in rats

Tlili, Mounira; Rouatbi, Sonia; Gandia, Fedoua; Hallegue, Dorsaf; Sriha, Badreddine; Yacoubi, Mohamed Taher; Krichah, Raja; Sakly, Mohsen; Rhouma, Khémais Ben; Vaudry, David; Wurtz, Olivier; Tebourbi, Olfa.

Braz. j. pharm. sci; 51 (3), 2015

The aim of this study was to investigate both functionally and structurally bronchodilator effects of Pituitary adenylate cyclase activating peptide (PACAP38) and acetyl-[Ala15, Ala20] PACAP38-polyamide, a potent PACAP38 analog, in rats challenged by methacholine (MeCh). Male Wistar rats were divided ran...

Adenilil Ciclasas/análisis, Receptores del Polipéptido Activador de la Adenilato-Ciclasa Hipofisaria/análisis, Cloruro de Metacolina/análisis, Cloruro de Metacolina/farmacocinética, Broncodilatadores/efectos adversos, Enfermedades Pulmonares/rehabilitación

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