TDZD-8 suppresses rheumatoid arthritis induced by collagen type II in rats: potential role of apoptosis and inflammation
Int. j. morphol; 39 (1), 2021
SUMMARY: Rheumatoid arthritis (RA) is considered an autoimmune disease distinguished by chronic synovial membrane inflammation, degraded cartilage, as well as bone destruction, which lead to joints pain and stiffness. The pathogenesis of RA involved at least two mechanisms: Cellular proliferation and act...
Tiadiazoles/administración & dosificación, Tiadiazoles/farmacología, Artritis Experimental/tratamiento farmacológico, Artritis Reumatoide/tratamiento farmacológico, Colágeno Tipo II/efectos adversos, Apoptosis, Inflamación, Ratas Wistar, Modelos Animales de Enfermedad, Interleucina-1beta, Inmunohistoquímica, Western Blotting