SUMMARY: Severe muscle injuries are common in accidents and have a delayed recovery of muscle integrity. In these cases, muscle suture surgery is the standard treatment. However, Platelet Rich Plasma (PRP), has been widely used in orthopedic injuries due to its growth factors. Thus, the objective of the ...
Abstract Purpose: To evaluate the in vivo response of photobiomodulation therapy associated with norbixin-based poly(hydroxybutyrate) membrane (PHB) in tenotomized calcaneal tendon. Methods: Thirty rats were randomly allocated to six groups (n=5 each): LED groups (L1, L2 and L3) and membrane + LED grou...
Tendón Calcáneo/efectos de los fármacos,
Tendón Calcáneo/efectos de la radiación,
Tendón Calcáneo/cirugía,
Carotenoides/farmacología,
Colágeno/farmacología,
Colágeno Tipo I/análisis,
Colágeno Tipo I/efectos de los fármacos,
Colágeno Tipo III/análisis,
Colágeno Tipo III/efectos de los fármacos,
Evaluación Preclínica de Medicamentos,
Fibroblastos/química,
Fibroblastos/efectos de los fármacos,
Hidroxibutiratos/farmacología,
Terapia por Luz de Baja Intensidad/métodos,
Prohibitinas,
Distribución Aleatoria,
Ratas Wistar,
Tendinopatía/radioterapia,
Tenotomía/métodos,
Cicatrización de Heridas/efectos de los fármacos,
Cicatrización de Heridas/efectos de la radiación
Nascimento, Lízia Daniela e Silva;
Nicolau, Renata Amadei;
Maia Filho, Antônio Luiz Martins;
Santos, José Zilton Lima Verde;
Fonseca, Khetyma Moreira;
Ferreira, Danniel Cabral Leão;
Sousa, Rayssilane Cardoso de;
Viana, Vicente Galber Freitas;
Carvalho, Luiz Fernando Meneses;
Figueredo-Silva, José.
Abstract Purpose: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair. Methods: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further ...
Tendón Calcáneo/efectos de los fármacos,
Tendón Calcáneo/patología,
Tendón Calcáneo/cirugía,
Carotenoides/farmacología,
Colágeno Tipo I/análisis,
Colágeno Tipo I/efectos de los fármacos,
Colágeno Tipo III/análisis,
Colágeno Tipo III/efectos de los fármacos,
Fibroblastos/efectos de los fármacos,
Hidroxibutiratos/farmacología,
Poliésteres/farmacología,
Ratas Wistar,
Valores de Referencia,
Regeneración/efectos de los fármacos,
Reproducibilidad de los Resultados,
Tenotomía/métodos
Abstract Purpose: To evaluate the effects and mechanisms of andiroba-based emulsion (ABE) topical treatment on full-thickness cutaneous wounds in rats. Methods: The wounds were harvested on days 3, 7, 15, and 20 post-surgery. Wound contraction rate, quantitative immunohistochemistry [macrophages, myofi...
Administración Cutánea,
Antiinflamatorios/farmacología,
Colágeno Tipo I/análisis,
Colágeno Tipo III/análisis,
Emulsiones,
Matriz Extracelular/efectos de los fármacos,
Inmunohistoquímica,
Meliaceae/química,
Miofibroblastos/efectos de los fármacos,
Aceites de Plantas/farmacología,
Ratas Wistar,
Reproducibilidad de los Resultados,
Piel/efectos de los fármacos,
Piel/patología,
Factor de Crecimiento Transformador beta3/análisis,
Factor de Crecimiento Transformador beta3/efectos de los fármacos,
Resultado del Tratamiento,
Cicatrización de Heridas/efectos de los fármacos
OBJECTIVES: Interest in elucidating the etiology of hernias has encouraged countless studies of musculoaponeurotic structures in individuals with and without hernias. Studies of hernia patients have firmly demonstrated a correlation between hernias and collagen alterations in their fascia. Diastasis rect...
ABSTRACT Background: Chronic kidney disease affects more than 500 million people worldwide. In this context, the uremic toxins present are related to worsening in tissue healing. Aim: Evaluate on healing of colonic anastomosis in uremic rats, serum and anatomopathological indicators, which may be rela...
Anastomosis Quirúrgica,
Proteína C-Reactiva/análisis,
Colágeno Tipo I/análisis,
Colágeno Tipo I/metabolismo,
Colágeno Tipo III/análisis,
Colágeno Tipo III/metabolismo,
Colon/cirugía,
Tejido de Granulación/fisiopatología,
Miofibroblastos/fisiología,
Nefrectomía,
Distribución Aleatoria,
Ratas Wistar,
Insuficiencia Renal Crónica/fisiopatología,
Herida Quirúrgica/fisiopatología,
Uremia/fisiopatología,
Cicatrización de Heridas/fisiología
Silva, Eduardo Nascimento;
Ribas-Filho, Jurandir Marcondes;
Czeczko, Nicolau Gregori;
Pachnicki, Jan Pawel Andrade;
Netto, Mário Rodrigues Montemor;
Lipinski, Leandro Cavalcante;
Noronha, Lucia de;
Colman, Joelmir;
Zeni, João Otavio;
Carvalho, Caroline Aragão de.
ABSTRACT PURPOSE: To assess the capsules formed by silicone implants coated with polyurethane foam and with a textured surface. METHODS: Sixty-four Wistar albinus rats were divided into two groups of 32 each using polyurethane foam and textured surface. The capsules around the implants were analyzed f...
Implantes de Mama/efectos adversos,
Materiales Biocompatibles Revestidos,
Reacción a Cuerpo Extraño/patología,
Contractura Capsular en Implantes/patología,
Poliuretanos/administración & dosificación,
Geles de Silicona/administración & dosificación,
Implantación de Mama/métodos,
Colágeno Tipo I/análisis,
Colágeno Tipo III/análisis,
Ratas Wistar,
Propiedades de Superficie
Thioacetamide (TAA) can induce various types of cirrhosis in the rat, including bridging fibrosis, biliary fibrosis, perisinusoidal/pericellular fibrosis and centrilobular fibrosis, in which different populations of hepatic myofibroblasts (MFs) are involved. The hepatic MFs can be classified into 3 group...
