LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Morphometric and molecular muscle remodeling after passive stretching in elderly female rats

Clinics; 75 (), 2020

OBJECTIVES: To determine the effects of three sessions of a passive stretching exercise protocol on the muscles of elderly female rats. METHODS: The effects of the stretching exercises on the soleus muscle were analyzed using immunohistochemistry [tissue inhibitors of matrix metalloproteinases (TIMP), t...

Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells

Jia, Peng; Hu, Yu; Li, Gang; Sun, Yuqin; Zhao, Jian; Fu, Jie; Lu, Cuixia; Liu, Bin.

Acta cir. bras; 32 (5), 2017

Abstract Purpose: To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs). Methods: Rat PASMCs were cultured and separated into a c...

Cromonas/farmacología, Colágeno Tipo III/metabolismo, Factor de Crecimiento del Tejido Conjuntivo/farmacología, Fibronectinas/metabolismo, Flavonoides/farmacología, Sistema de Señalización de MAP Quinasas/efectos de los fármacos, Células Cultivadas, Colágeno Tipo III/genética, Factor de Crecimiento del Tejido Conjuntivo/metabolismo, Fibronectinas/genética, Expresión Génica/efectos de los fármacos, Regulación de la Expresión Génica, Modelos Animales, Miocitos del Músculo Liso/citología, Miocitos del Músculo Liso/metabolismo, Fosfatidilinositol 3-Quinasas/metabolismo, Proteínas Proto-Oncogénicas c-akt/metabolismo, Arteria Pulmonar/citología, Ratas Sprague-Dawley

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