El uso de antirretrovirales (ARV) en el embarazo, el parto y el
recién nacido y la aplicación de tratamientos combinados en los
niños se han asociado con una disminución del sida en pediatría
y el aumento de la sobrevida. La introducción de los inhibidores
de integrasa en una dosis diaria ha elimin...
A pesquisa busca técnicas alternativas para expansão da vida de prateleira dos alimentos, isto tem impulsionado estudos sobre a utilização de conservantes naturais, tais como as bacteriocinas e óleos essenciais, que são considerados agentes antimicrobianos naturais. No entanto estes antimicrobianos...
Abstract Piper nigrum (black pepper) is used in Indian traditional medicine and its main alkaloid, Piperine (PIP), presents antioxidant, antitumor and neuroprotective pharmacological properties. This substance is insoluble in aqueous media and can irritate the gastrointestinal tract. Aiming to avoid thes...
Piper nigrum/efectos adversos,
Composición de Medicamentos/instrumentación,
d0002840,
Alcaloides/efectos adversos,
Antioxidantes/efectos adversos,
Análisis Espectral/métodos,
Comprimidos/clasificación,
Medicina Tradicional/instrumentación,
Microscopía Electrónica de Rastreo/métodos,
Tracto Gastrointestinal/anomalías,
Técnicas In Vitro/métodos
Abstract A stability-indicating HPLC-DAD method was developed and validated for the simultaneous determination of dasabuvir and its degradation products in the pharmaceutical formulation. The proposed method utilized a Symmetry® C18 (4.6 x 75 mm, 3.5 µm) column, and the mobile phase consisted of an iso...
For a drug to excerpt pharmacological action after oral intake, it first needs to be released from the formulation, get into solution (dissolve), be absorbed, and reach the systemic circulation. Since only solubilized drugs can be absorbed, and thus have therapeutic effect, the understanding of the disso...
Optimización de Procesos,
Acciones Farmacológicas,
Composición de Medicamentos,
Concentración de Iones de Hidrógeno,
Desarrollo de Medicamentos/instrumentación,
Eficiencia,
Liberación de Fármacos,
Metronidazol/efectos adversos,
Necesidades y Demandas de Servicios de Salud/clasificación,
Preparaciones Farmacéuticas/análisis,
Química Farmacéutica/instrumentación,
Disolución
The antiparasitic niclosamide has shown promising anticancer activity in preclinical studies against several types of cancer, such as colorectal and prostate. Thus, the objective of this work was to develop innovative formulations for the repositioning of niclosamide as an anticancer agent. In chapter I,...
Abstract The objective of the present investigation was to design, optimize and characterize the gastro retentive floating levofloxacin tablets and perform in-vivo evaluation using radiographic imaging. The floating tablets were prepared by using polymers i.e hydroxy propyl methyl cellulose (HPMC-K4M) an...
RESUMO Objetivo: Identificar o volume residual em frascos-ampola, após o preparo de injetáveis, associando os erros relacionados a subdoses com as classes dos medicamentos. Método: Estudo descritivo, de abordagem quantitativa. Os dados foram coletados no período de dezembro de 2020 a setembro de 20...
Abstract Dexchlorpheniramine is a first-generation classical antihistamine, clinically used to treat allergies. The main objective of our study was to evaluate the effects of the dexchlorpheniramine reference standard (DCPA Ref. St) and a pharmaceutical formula on DNA in human peripheral blood mononuclea...
Abstract Sustained release matrix tablets of 100 mg losartan potassium HCl were fabricated with two
release retarding polymers namely HPMC K100 M and affinisol by direct compression method.
Nine trial formulations were prepared by varying content of these polymers, each from 50 mg
to 100 mg; keeping the...
